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  <xsd:element id="kmph_LiabilitiesFairValueDisclosureEstimatedAmountOfWeightedaverageProbabilityOfFundamentalChange" name="LiabilitiesFairValueDisclosureEstimatedAmountOfWeightedaverageProbabilityOfFundamentalChange" nillable="true" substitutionGroup="xbrli:item" type="xbrli:monetaryItemType" xbrli:balance="credit" xbrli:periodType="instant"/>
  <xsd:element id="kmph_LiabilitiesFairValueDisclosureEstimatedAmountOfWeightedaverageProbabilityOfLiquidityEvent" name="LiabilitiesFairValueDisclosureEstimatedAmountOfWeightedaverageProbabilityOfLiquidityEvent" nillable="true" substitutionGroup="xbrli:item" type="xbrli:monetaryItemType" xbrli:balance="credit" xbrli:periodType="instant"/>
  <xsd:element id="kmph_LiabilitiesFairValueDisclosureIncreaseFromTenPercentIncreaseInEnterpriseValue" name="LiabilitiesFairValueDisclosureIncreaseFromTenPercentIncreaseInEnterpriseValue" nillable="true" substitutionGroup="xbrli:item" type="xbrli:monetaryItemType" xbrli:balance="credit" xbrli:periodType="duration"/>
  <xsd:element id="kmph_LicenseAgreementAdditionalPaymentsUponAchievementOfSalesMilestone" name="LicenseAgreementAdditionalPaymentsUponAchievementOfSalesMilestone" nillable="true" substitutionGroup="xbrli:item" type="xbrli:monetaryItemType" xbrli:balance="debit" xbrli:periodType="duration"/>
  <xsd:element id="kmph_LicenseAgreementEstimatedPreLaunchPaymentsAndReimbursements" name="LicenseAgreementEstimatedPreLaunchPaymentsAndReimbursements" nillable="true" substitutionGroup="xbrli:item" type="xbrli:monetaryItemType" xbrli:balance="debit" xbrli:periodType="duration"/>
  <xsd:element id="kmph_LicenseAgreementPercentageOfNetProfits" name="LicenseAgreementPercentageOfNetProfits" nillable="true" substitutionGroup="xbrli:item" type="dtr-types:percentItemType" xbrli:periodType="duration"/>
  <xsd:element id="kmph_LicenseAgreementPrelaunchPaymentReimbursementWithin10DaysOfInitialAdoptionMilestone" name="LicenseAgreementPrelaunchPaymentReimbursementWithin10DaysOfInitialAdoptionMilestone" nillable="true" substitutionGroup="xbrli:item" type="xbrli:monetaryItemType" xbrli:balance="debit" xbrli:periodType="duration"/>
  <xsd:element abstract="true" id="kmph_LincolnParkMember" name="LincolnParkMember" nillable="true" substitutionGroup="xbrli:item" type="dtr-types:domainItemType" xbrli:periodType="duration"/>
  <xsd:element id="kmph_LossOnSubleaseAndDisposalOfPropertyAndEquipment" name="LossOnSubleaseAndDisposalOfPropertyAndEquipment" nillable="true" substitutionGroup="xbrli:item" type="xbrli:monetaryItemType" xbrli:balance="debit" xbrli:periodType="duration"/>
  <xsd:element id="kmph_MaximumPercentOfCommonStockOwnershipAllowedPerHolderAfterWarrantExerciseUponHoldersSelection" name="MaximumPercentOfCommonStockOwnershipAllowedPerHolderAfterWarrantExerciseUponHoldersSelection" nillable="true" substitutionGroup="xbrli:item" type="dtr-types:percentItemType" xbrli:periodType="instant"/>
  <xsd:element id="kmph_MaximumPercentOfCommonStockOwnershipAllowedPerHolderUponWarrantExercise" name="MaximumPercentOfCommonStockOwnershipAllowedPerHolderUponWarrantExercise" nillable="true" substitutionGroup="xbrli:item" type="dtr-types:percentItemType" xbrli:periodType="instant"/>
  <xsd:element abstract="true" id="kmph_NoteToFinancialStatementDetailsTextual" name="NoteToFinancialStatementDetailsTextual" nillable="true" substitutionGroup="xbrli:item" type="xbrli:stringItemType" xbrli:periodType="duration"/>
  <xsd:element abstract="true" id="kmph_NotesToFinancialStatements" name="NotesToFinancialStatements" nillable="true" substitutionGroup="xbrli:item" type="xbrli:stringItemType" xbrli:periodType="duration"/>
  <xsd:element abstract="true" id="kmph_NotesToFinancialStatementsAbstract" name="NotesToFinancialStatementsAbstract" nillable="true" substitutionGroup="xbrli:item" type="xbrli:stringItemType" xbrli:periodType="duration"/>
  <xsd:element id="kmph_OperatingAndFinanceLeaseLiabilityMaturityTableTextBlock" name="OperatingAndFinanceLeaseLiabilityMaturityTableTextBlock" nillable="true" substitutionGroup="xbrli:item" type="dtr-types:textBlockItemType" xbrli:periodType="duration"/>
  <xsd:element abstract="true" id="kmph_OperatingLeaseLiabilitiesLessCurrentPortionMember" name="OperatingLeaseLiabilitiesLessCurrentPortionMember" nillable="true" substitutionGroup="xbrli:item" type="dtr-types:domainItemType" xbrli:periodType="duration"/>
  <xsd:element abstract="true" id="kmph_OperatingLeaseRightOfUseAssetsMember" name="OperatingLeaseRightOfUseAssetsMember" nillable="true" substitutionGroup="xbrli:item" type="dtr-types:domainItemType" xbrli:periodType="duration"/>
  <xsd:element abstract="true" id="kmph_OptionalExchangePrincipalAmountConversionFeatureMember" name="OptionalExchangePrincipalAmountConversionFeatureMember" nillable="true" substitutionGroup="xbrli:item" type="dtr-types:domainItemType" xbrli:periodType="duration"/>
  <xsd:element abstract="true" id="kmph_OptionalExchangePrincipalAmountMember" name="OptionalExchangePrincipalAmountMember" nillable="true" substitutionGroup="xbrli:item" type="dtr-types:domainItemType" xbrli:periodType="duration"/>
  <xsd:element id="kmph_OverAllotmentOptionsNumberOfSharesForWarrants" name="OverAllotmentOptionsNumberOfSharesForWarrants" nillable="true" substitutionGroup="xbrli:item" type="xbrli:sharesItemType" xbrli:periodType="duration"/>
  <xsd:element id="kmph_OverAllotmentOptionsPercentageOfCommonStockOutstandingForWarrants" name="OverAllotmentOptionsPercentageOfCommonStockOutstandingForWarrants" nillable="true" substitutionGroup="xbrli:item" type="dtr-types:percentItemType" xbrli:periodType="duration"/>
  <xsd:element abstract="true" id="kmph_PaycheckProtectionProgramCaresActMember" name="PaycheckProtectionProgramCaresActMember" nillable="true" substitutionGroup="xbrli:item" type="dtr-types:domainItemType" xbrli:periodType="duration"/>
  <xsd:element id="kmph_PercentageOfConsultingServicesAndOutOfPocketThirdPartyResearchAndDevelopmentCostsRecognized" name="PercentageOfConsultingServicesAndOutOfPocketThirdPartyResearchAndDevelopmentCostsRecognized" nillable="true" substitutionGroup="xbrli:item" type="dtr-types:percentItemType" xbrli:periodType="instant"/>
  <xsd:element id="kmph_PlacementAgentFeePercentage" name="PlacementAgentFeePercentage" nillable="true" substitutionGroup="xbrli:item" type="dtr-types:percentItemType" xbrli:periodType="instant"/>
  <xsd:element abstract="true" id="kmph_PossibleFutureIssuancesUnderEmployeeStockPurchasePlansMember" name="PossibleFutureIssuancesUnderEmployeeStockPurchasePlansMember" nillable="true" substitutionGroup="xbrli:item" type="dtr-types:domainItemType" xbrli:periodType="duration"/>
  <xsd:element abstract="true" id="kmph_PossibleFutureIssuancesUnderEquityIncentivePlansMember" name="PossibleFutureIssuancesUnderEquityIncentivePlansMember" nillable="true" substitutionGroup="xbrli:item" type="dtr-types:domainItemType" xbrli:periodType="duration"/>
  <xsd:element id="kmph_PreferredStockSharesAuthorizedEliminated" name="PreferredStockSharesAuthorizedEliminated" nillable="true" substitutionGroup="xbrli:item" type="xbrli:sharesItemType" xbrli:periodType="duration"/>
  <xsd:element abstract="true" id="kmph_PrefundedWarrantsMember" name="PrefundedWarrantsMember" nillable="true" substitutionGroup="xbrli:item" type="dtr-types:domainItemType" xbrli:periodType="duration"/>
  <xsd:element id="kmph_ProceedsFromUnderwrittenPublicOfferingNet" name="ProceedsFromUnderwrittenPublicOfferingNet" nillable="true" substitutionGroup="xbrli:item" type="xbrli:monetaryItemType" xbrli:balance="debit" xbrli:periodType="duration"/>
  <xsd:element abstract="true" id="kmph_PropertyAndEquipmentAtCostMember" name="PropertyAndEquipmentAtCostMember" nillable="true" substitutionGroup="xbrli:item" type="dtr-types:domainItemType" xbrli:periodType="duration"/>
  <xsd:element abstract="true" id="kmph_PropertyAndEquipmentNetMember" name="PropertyAndEquipmentNetMember" nillable="true" substitutionGroup="xbrli:item" type="dtr-types:domainItemType" xbrli:periodType="duration"/>
  <xsd:element abstract="true" id="kmph_PublicOfferingWarrantsMember" name="PublicOfferingWarrantsMember" nillable="true" substitutionGroup="xbrli:item" type="dtr-types:domainItemType" xbrli:periodType="duration"/>
  <xsd:element id="kmph_PurchaseAgreementAdditionalSharesToBeIssuedAsCommitmentShares" name="PurchaseAgreementAdditionalSharesToBeIssuedAsCommitmentShares" nillable="true" substitutionGroup="xbrli:item" type="xbrli:sharesItemType" xbrli:periodType="duration"/>
  <xsd:element id="kmph_PurchaseAgreementMaximumAdditionalSharesAvailableForPurchaseDuringTheOptionalPeriod" name="PurchaseAgreementMaximumAdditionalSharesAvailableForPurchaseDuringTheOptionalPeriod" nillable="true" substitutionGroup="xbrli:item" type="xbrli:sharesItemType" xbrli:periodType="duration"/>
  <xsd:element id="kmph_PurchaseAgreementMaximumSharesToBeIssued" name="PurchaseAgreementMaximumSharesToBeIssued" nillable="true" substitutionGroup="xbrli:item" type="xbrli:sharesItemType" xbrli:periodType="duration"/>
  <xsd:element id="kmph_PurchaseAgreementOptionalPeriodToShares" name="PurchaseAgreementOptionalPeriodToShares" nillable="true" substitutionGroup="xbrli:item" type="xbrli:durationItemType" xbrli:periodType="duration"/>
  <xsd:element id="kmph_PurchaseAgreementTerm" name="PurchaseAgreementTerm" nillable="true" substitutionGroup="xbrli:item" type="xbrli:durationItemType" xbrli:periodType="duration"/>
  <xsd:element id="kmph_RegulatoryMilestoneRevenueToBeEarnedFollowingFdaAcceptance" name="RegulatoryMilestoneRevenueToBeEarnedFollowingFdaAcceptance" nillable="true" substitutionGroup="xbrli:item" type="xbrli:monetaryItemType" xbrli:balance="credit" xbrli:periodType="instant"/>
  <xsd:element id="kmph_RevenueRecognitionMilestoneMethodAdditionalRevenueToBeRecognized" name="RevenueRecognitionMilestoneMethodAdditionalRevenueToBeRecognized" nillable="true" substitutionGroup="xbrli:item" type="xbrli:monetaryItemType" xbrli:balance="credit" xbrli:periodType="instant"/>
  <xsd:element id="kmph_RevenueRecognitionMilestoneMethodRevenueToBeRecognized" name="RevenueRecognitionMilestoneMethodRevenueToBeRecognized" nillable="true" substitutionGroup="xbrli:item" type="xbrli:monetaryItemType" xbrli:balance="credit" xbrli:periodType="instant"/>
  <xsd:element abstract="true" id="kmph_ReverseStockSplitMember" name="ReverseStockSplitMember" nillable="true" substitutionGroup="xbrli:item" type="dtr-types:domainItemType" xbrli:periodType="duration"/>
  <xsd:element abstract="true" id="kmph_RothCapitalPartnersLLCMember" name="RothCapitalPartnersLLCMember" nillable="true" substitutionGroup="xbrli:item" type="dtr-types:domainItemType" xbrli:periodType="duration"/>
  <xsd:element id="kmph_RoyaltyAndDirectContractAcquisitionCosts" name="RoyaltyAndDirectContractAcquisitionCosts" nillable="true" substitutionGroup="xbrli:item" type="xbrli:monetaryItemType" xbrli:balance="debit" xbrli:periodType="duration"/>
  <xsd:element id="kmph_RoyaltyRevenuePercent" name="RoyaltyRevenuePercent" nillable="true" substitutionGroup="xbrli:item" type="dtr-types:percentItemType" xbrli:periodType="duration"/>
  <xsd:element id="kmph_SaleOfSecuritiesValueAvailableToIssue" name="SaleOfSecuritiesValueAvailableToIssue" nillable="true" substitutionGroup="xbrli:item" type="xbrli:monetaryItemType" xbrli:balance="credit" xbrli:periodType="instant"/>
  <xsd:element id="kmph_SaleOfStockAuthorizedAmount" name="SaleOfStockAuthorizedAmount" nillable="true" substitutionGroup="xbrli:item" type="xbrli:monetaryItemType" xbrli:balance="credit" xbrli:periodType="instant"/>
  <xsd:element id="kmph_ScheduleOfAuthorizedSharesOfCommonStockReservedForFutureIssuanceTableTextBlock" name="ScheduleOfAuthorizedSharesOfCommonStockReservedForFutureIssuanceTableTextBlock" nillable="true" substitutionGroup="xbrli:item" type="dtr-types:textBlockItemType" xbrli:periodType="duration"/>
  <xsd:element id="kmph_ScheduleOfLeasesBalanceSheetInformationTableTextBlock" name="ScheduleOfLeasesBalanceSheetInformationTableTextBlock" nillable="true" substitutionGroup="xbrli:item" type="dtr-types:textBlockItemType" xbrli:periodType="duration"/>
  <xsd:element id="kmph_ScheduleOfLeasesCashFlowInformationTableTextBlock" name="ScheduleOfLeasesCashFlowInformationTableTextBlock" nillable="true" substitutionGroup="xbrli:item" type="dtr-types:textBlockItemType" xbrli:periodType="duration"/>
  <xsd:element id="kmph_ScheduleOfPreferredStockTableTextBlock" name="ScheduleOfPreferredStockTableTextBlock" nillable="true" substitutionGroup="xbrli:item" type="dtr-types:textBlockItemType" xbrli:periodType="duration"/>
  <xsd:element abstract="true" id="kmph_SeriesAConvertiblePreferredStockMember" name="SeriesAConvertiblePreferredStockMember" nillable="true" substitutionGroup="xbrli:item" type="dtr-types:domainItemType" xbrli:periodType="duration"/>
  <xsd:element abstract="true" id="kmph_SeriesB1ConvertiblePreferredStockMember" name="SeriesB1ConvertiblePreferredStockMember" nillable="true" substitutionGroup="xbrli:item" type="dtr-types:domainItemType" xbrli:periodType="duration"/>
  <xsd:element abstract="true" id="kmph_SeriesB2ConvertiblePreferredStockMember" name="SeriesB2ConvertiblePreferredStockMember" nillable="true" substitutionGroup="xbrli:item" type="dtr-types:domainItemType" xbrli:periodType="duration"/>
  <xsd:element abstract="true" id="kmph_SeriesDRedeemableConvertiblePreferredStockMember" name="SeriesDRedeemableConvertiblePreferredStockMember" nillable="true" substitutionGroup="xbrli:item" type="dtr-types:domainItemType" xbrli:periodType="duration"/>
  <xsd:element id="kmph_SeveranceCharges" name="SeveranceCharges" nillable="true" substitutionGroup="xbrli:item" type="xbrli:monetaryItemType" xbrli:balance="debit" xbrli:periodType="duration"/>
  <xsd:element abstract="true" id="kmph_SeveranceExpenseMember" name="SeveranceExpenseMember" nillable="true" substitutionGroup="xbrli:item" type="dtr-types:domainItemType" xbrli:periodType="duration"/>
  <xsd:element id="kmph_SharebasedCompensationArrangementBySharebasedPaymentAwardNumberOfSharesReservedForIssuanceIncrementalPercentageOfCapitalStockOutstanding" name="SharebasedCompensationArrangementBySharebasedPaymentAwardNumberOfSharesReservedForIssuanceIncrementalPercentageOfCapitalStockOutstanding" nillable="true" substitutionGroup="xbrli:item" type="dtr-types:percentItemType" xbrli:periodType="duration"/>
  <xsd:element id="kmph_SharesAndWarrantsIssuedPricePerShare" name="SharesAndWarrantsIssuedPricePerShare" nillable="true" substitutionGroup="xbrli:item" type="dtr-types:perShareItemType" xbrli:periodType="instant"/>
  <xsd:element id="kmph_StockIssuedDuringPeriodSharesReverseStockSplitsAdjustmentForFractionalShare" name="StockIssuedDuringPeriodSharesReverseStockSplitsAdjustmentForFractionalShare" nillable="true" substitutionGroup="xbrli:item" type="xbrli:sharesItemType" xbrli:periodType="duration"/>
  <xsd:element id="kmph_StockIssuedDuringPeriodSharesWarrantExercises" name="StockIssuedDuringPeriodSharesWarrantExercises" nillable="true" substitutionGroup="xbrli:item" type="xbrli:sharesItemType" xbrli:periodType="duration"/>
  <xsd:element id="kmph_StockIssuedDuringPeriodValueWarrantExercises" name="StockIssuedDuringPeriodValueWarrantExercises" nillable="true" substitutionGroup="xbrli:item" type="xbrli:monetaryItemType" xbrli:balance="credit" xbrli:periodType="duration"/>
  <xsd:element abstract="true" id="kmph_TermNotesMember" name="TermNotesMember" nillable="true" substitutionGroup="xbrli:item" type="dtr-types:domainItemType" xbrli:periodType="duration"/>
  <xsd:element abstract="true" id="kmph_The2019NotesConvertedToCommonStockMember" name="The2019NotesConvertedToCommonStockMember" nillable="true" substitutionGroup="xbrli:item" type="dtr-types:domainItemType" xbrli:periodType="duration"/>
  <xsd:element abstract="true" id="kmph_The2019NotesMember" name="The2019NotesMember" nillable="true" substitutionGroup="xbrli:item" type="dtr-types:domainItemType" xbrli:periodType="duration"/>
  <xsd:element abstract="true" id="kmph_TheDecember2019AndJanuary2020NotesMember" name="TheDecember2019AndJanuary2020NotesMember" nillable="true" substitutionGroup="xbrli:item" type="dtr-types:domainItemType" xbrli:periodType="duration"/>
  <xsd:element abstract="true" id="kmph_TheDecember2020ExchangeAgreementMember" name="TheDecember2020ExchangeAgreementMember" nillable="true" substitutionGroup="xbrli:item" type="dtr-types:domainItemType" xbrli:periodType="duration"/>
  <xsd:element abstract="true" id="kmph_TheFacilityNotesMember" name="TheFacilityNotesMember" nillable="true" substitutionGroup="xbrli:item" type="dtr-types:domainItemType" xbrli:periodType="duration"/>
  <xsd:element abstract="true" id="kmph_TwoThousandFourteenEquityIncentivePlanMember" name="TwoThousandFourteenEquityIncentivePlanMember" nillable="true" substitutionGroup="xbrli:item" type="dtr-types:domainItemType" xbrli:periodType="duration"/>
  <xsd:element abstract="true" id="kmph_TwoThousandTwentyOneNotesMember" name="TwoThousandTwentyOneNotesMember" nillable="true" substitutionGroup="xbrli:item" type="dtr-types:domainItemType" xbrli:periodType="duration"/>
  <xsd:element abstract="true" id="kmph_UnderwriterWarrantsMember" name="UnderwriterWarrantsMember" nillable="true" substitutionGroup="xbrli:item" type="dtr-types:domainItemType" xbrli:periodType="duration"/>
  <xsd:element abstract="true" id="kmph_UnderwritingAgreementMember" name="UnderwritingAgreementMember" nillable="true" substitutionGroup="xbrli:item" type="dtr-types:domainItemType" xbrli:periodType="duration"/>
  <xsd:element abstract="true" id="kmph_UnderwrittenPublicOfferingMember" name="UnderwrittenPublicOfferingMember" nillable="true" substitutionGroup="xbrli:item" type="dtr-types:domainItemType" xbrli:periodType="duration"/>
  <xsd:element abstract="true" id="kmph_UndesignatedPreferredStockMember" name="UndesignatedPreferredStockMember" nillable="true" substitutionGroup="xbrli:item" type="dtr-types:domainItemType" xbrli:periodType="duration"/>
  <xsd:element abstract="true" id="kmph_WarrantIssuedToKVKMember" name="WarrantIssuedToKVKMember" nillable="true" substitutionGroup="xbrli:item" type="dtr-types:domainItemType" xbrli:periodType="duration"/>
  <xsd:element id="kmph_WarrantsIssued" name="WarrantsIssued" nillable="true" substitutionGroup="xbrli:item" type="xbrli:monetaryItemType" xbrli:balance="credit" xbrli:periodType="duration"/>
  <xsd:element abstract="true" id="kmph_WarrantsIssuedInConnectionWithJanuary2021InducementTransactionMember" name="WarrantsIssuedInConnectionWithJanuary2021InducementTransactionMember" nillable="true" substitutionGroup="xbrli:item" type="dtr-types:domainItemType" xbrli:periodType="duration"/>
  <xsd:element abstract="true" id="kmph_WarrantsIssuedInConnectionWithJune2021InducementTransactionMember" name="WarrantsIssuedInConnectionWithJune2021InducementTransactionMember" nillable="true" substitutionGroup="xbrli:item" type="dtr-types:domainItemType" xbrli:periodType="duration"/>
  <xsd:element id="kmph_WarrantsIssuedUponExchangePercentageOfSharesIssuedUponExercise" name="WarrantsIssuedUponExchangePercentageOfSharesIssuedUponExercise" nillable="true" substitutionGroup="xbrli:item" type="dtr-types:percentItemType" xbrli:periodType="instant"/>
  <xsd:element abstract="true" id="kmph_WarrantsToPurchaseCommonStockMember" name="WarrantsToPurchaseCommonStockMember" nillable="true" substitutionGroup="xbrli:item" type="dtr-types:domainItemType" xbrli:periodType="duration"/>
  <xsd:element abstract="true" id="kmph_WeightedAverageProbabilityOfFundamentalChangeMember" name="WeightedAverageProbabilityOfFundamentalChangeMember" nillable="true" substitutionGroup="xbrli:item" type="dtr-types:domainItemType" xbrli:periodType="duration"/>
  <xsd:element abstract="true" id="kmph_WeightedAverageProbabilityOfLiquidityEventMember" name="WeightedAverageProbabilityOfLiquidityEventMember" nillable="true" substitutionGroup="xbrli:item" type="dtr-types:domainItemType" xbrli:periodType="duration"/>
  <xsd:element abstract="true" id="kmph_statement-statement-note-e-preferred-stock-and-warrants-preferred-stock-issued-and-outstanding-details" name="statement-statement-note-e-preferred-stock-and-warrants-preferred-stock-issued-and-outstanding-details" nillable="true" substitutionGroup="xbrli:item" type="xbrli:stringItemType" xbrli:periodType="duration"/>
  <xsd:element abstract="true" id="kmph_statement-statement-note-e-preferred-stock-and-warrants-tables" name="statement-statement-note-e-preferred-stock-and-warrants-tables" nillable="true" substitutionGroup="xbrli:item" type="xbrli:stringItemType" xbrli:periodType="duration"/>
  <xsd:element abstract="true" id="kmph_statement-statement-note-f-common-stock-and-warrants-common-stock-activity-details" name="statement-statement-note-f-common-stock-and-warrants-common-stock-activity-details" nillable="true" substitutionGroup="xbrli:item" type="xbrli:stringItemType" xbrli:periodType="duration"/>
  <xsd:element abstract="true" id="kmph_statement-statement-note-f-common-stock-and-warrants-reserved-authorized-shares-of-common-stock-for-future-issuance-details" name="statement-statement-note-f-common-stock-and-warrants-reserved-authorized-shares-of-common-stock-for-future-issuance-details" nillable="true" substitutionGroup="xbrli:item" type="xbrli:stringItemType" xbrli:periodType="duration"/>
  <xsd:element abstract="true" id="kmph_statement-statement-note-f-common-stock-and-warrants-tables" name="statement-statement-note-f-common-stock-and-warrants-tables" nillable="true" substitutionGroup="xbrli:item" type="xbrli:stringItemType" xbrli:periodType="duration"/>
  <xsd:element abstract="true" id="kmph_statement-statement-note-g-stockbased-compensation-stockbased-compensation-expense-details" name="statement-statement-note-g-stockbased-compensation-stockbased-compensation-expense-details" nillable="true" substitutionGroup="xbrli:item" type="xbrli:stringItemType" xbrli:periodType="duration"/>
  <xsd:element abstract="true" id="kmph_statement-statement-note-g-stockbased-compensation-tables" name="statement-statement-note-g-stockbased-compensation-tables" nillable="true" substitutionGroup="xbrli:item" type="xbrli:stringItemType" xbrli:periodType="duration"/>
  <xsd:element abstract="true" id="kmph_statement-statement-note-h-fair-value-of-financial-instruments-assets-and-liabilities-measured-at-fair-value-on-recurring-basis-details" name="statement-statement-note-h-fair-value-of-financial-instruments-assets-and-liabilities-measured-at-fair-value-on-recurring-basis-details" nillable="true" substitutionGroup="xbrli:item" type="xbrli:stringItemType" xbrli:periodType="duration"/>
  <xsd:element abstract="true" id="kmph_statement-statement-note-h-fair-value-of-financial-instruments-reconciliation-of-beginning-and-ending-balances-for-derivative-and-warrant-liability-measured-at-fair-value-on-recurring-basis-details" name="statement-statement-note-h-fair-value-of-financial-instruments-reconciliation-of-beginning-and-ending-balances-for-derivative-and-warrant-liability-measured-at-fair-value-on-recurring-basis-details" nillable="true" substitutionGroup="xbrli:item" type="xbrli:stringItemType" xbrli:periodType="duration"/>
  <xsd:element abstract="true" id="kmph_statement-statement-note-h-fair-value-of-financial-instruments-tables" name="statement-statement-note-h-fair-value-of-financial-instruments-tables" nillable="true" substitutionGroup="xbrli:item" type="xbrli:stringItemType" xbrli:periodType="duration"/>
  <xsd:element abstract="true" id="kmph_statement-statement-note-i-net-income-loss-per-share-antidilutive-securities-details" name="statement-statement-note-i-net-income-loss-per-share-antidilutive-securities-details" nillable="true" substitutionGroup="xbrli:item" type="xbrli:stringItemType" xbrli:periodType="duration"/>
  <xsd:element abstract="true" id="kmph_statement-statement-note-i-net-income-loss-per-share-antidilutive-securities-details-parentheticals" name="statement-statement-note-i-net-income-loss-per-share-antidilutive-securities-details-parentheticals" nillable="true" substitutionGroup="xbrli:item" type="xbrli:stringItemType" xbrli:periodType="duration"/>
  <xsd:element abstract="true" id="kmph_statement-statement-note-i-net-income-loss-per-share-earnings-per-share-details" name="statement-statement-note-i-net-income-loss-per-share-earnings-per-share-details" nillable="true" substitutionGroup="xbrli:item" type="xbrli:stringItemType" xbrli:periodType="duration"/>
  <xsd:element abstract="true" id="kmph_statement-statement-note-i-net-income-loss-per-share-tables" name="statement-statement-note-i-net-income-loss-per-share-tables" nillable="true" substitutionGroup="xbrli:item" type="xbrli:stringItemType" xbrli:periodType="duration"/>
  <xsd:element abstract="true" id="kmph_statement-statement-note-k-leases-lease-cost-details" name="statement-statement-note-k-leases-lease-cost-details" nillable="true" substitutionGroup="xbrli:item" type="xbrli:stringItemType" xbrli:periodType="duration"/>
  <xsd:element abstract="true" id="kmph_statement-statement-note-k-leases-maturities-of-lease-liabilities-details" name="statement-statement-note-k-leases-maturities-of-lease-liabilities-details" nillable="true" substitutionGroup="xbrli:item" type="xbrli:stringItemType" xbrli:periodType="duration"/>
  <xsd:element abstract="true" id="kmph_statement-statement-note-k-leases-supplement-balance-sheet-information-related-to-lease-details" name="statement-statement-note-k-leases-supplement-balance-sheet-information-related-to-lease-details" nillable="true" substitutionGroup="xbrli:item" type="xbrli:stringItemType" xbrli:periodType="duration"/>
  <xsd:element abstract="true" id="kmph_statement-statement-note-k-leases-supplement-cash-flow-information-related-to-leases-details" name="statement-statement-note-k-leases-supplement-cash-flow-information-related-to-leases-details" nillable="true" substitutionGroup="xbrli:item" type="xbrli:stringItemType" xbrli:periodType="duration"/>
  <xsd:element abstract="true" id="kmph_statement-statement-note-k-leases-tables" name="statement-statement-note-k-leases-tables" nillable="true" substitutionGroup="xbrli:item" type="xbrli:stringItemType" xbrli:periodType="duration"/>
  <xsd:element abstract="true" id="kmph_statement-statement-significant-accounting-policies-policies" name="statement-statement-significant-accounting-policies-policies" nillable="true" substitutionGroup="xbrli:item" type="xbrli:stringItemType" xbrli:periodType="duration"/>
</xsd:schema>
