<?xml version="1.0" encoding="UTF-8"?>

<!--XBRL Document Created with the Workiva Platform-->
<!--Copyright 2026 Workiva-->
<!--r:019ff749-bcfd-7638-b447-536edd020dde,g:54819fd2-1aad-4108-b0ea-736179dd4aa7-->
<link:linkbase xmlns:link="http://www.xbrl.org/2003/linkbase" xmlns:xlink="http://www.w3.org/1999/xlink" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance" xsi:schemaLocation="http://www.xbrl.org/2003/linkbase http://www.xbrl.org/2003/xbrl-linkbase-2003-12-31.xsd">
  <link:arcroleRef arcroleURI="https://xbrl.org/2023/arcrole/summation-item" xlink:type="simple" xlink:href="https://www.xbrl.org/2023/calculation-1.1.xsd#summation-item"/>
  <link:roleRef roleURI="http://zevra.com/role/UNAUDITEDCONDENSEDCONSOLIDATEDBALANCESHEETS" xlink:type="simple" xlink:href="zvra-20260930.xsd#UNAUDITEDCONDENSEDCONSOLIDATEDBALANCESHEETS"/>
  <link:calculationLink xlink:role="http://zevra.com/role/UNAUDITEDCONDENSEDCONSOLIDATEDBALANCESHEETS" xlink:type="extended">
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_AssetsCurrent_019ff749-bda3-7788-8317-5643373e2eaf" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_AssetsCurrent"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_AvailableForSaleSecuritiesDebtSecuritiesCurrent_019ff749-bda3-7817-9292-6d178ac91cad" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_AvailableForSaleSecuritiesDebtSecuritiesCurrent"/>
    <link:calculationArc order="1" weight="1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_us-gaap_AssetsCurrent_019ff749-bda3-7788-8317-5643373e2eaf" xlink:to="loc_us-gaap_AvailableForSaleSecuritiesDebtSecuritiesCurrent_019ff749-bda3-7817-9292-6d178ac91cad" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_CashAndCashEquivalentsAtCarryingValue_019ff749-bda3-7ea3-b93c-da2f4be9dc9b" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_CashAndCashEquivalentsAtCarryingValue"/>
    <link:calculationArc order="2" weight="1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_us-gaap_AssetsCurrent_019ff749-bda3-7788-8317-5643373e2eaf" xlink:to="loc_us-gaap_CashAndCashEquivalentsAtCarryingValue_019ff749-bda3-7ea3-b93c-da2f4be9dc9b" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_PrepaidExpenseAndOtherAssetsCurrent_019ff749-bda3-7a6c-9d54-16e274eb70d5" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_PrepaidExpenseAndOtherAssetsCurrent"/>
    <link:calculationArc order="3" weight="1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_us-gaap_AssetsCurrent_019ff749-bda3-7788-8317-5643373e2eaf" xlink:to="loc_us-gaap_PrepaidExpenseAndOtherAssetsCurrent_019ff749-bda3-7a6c-9d54-16e274eb70d5" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_AccountsAndOtherReceivablesNetCurrent_019ff749-bda3-76da-ab11-303fe81921e2" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_AccountsAndOtherReceivablesNetCurrent"/>
    <link:calculationArc order="4" weight="1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_us-gaap_AssetsCurrent_019ff749-bda3-7788-8317-5643373e2eaf" xlink:to="loc_us-gaap_AccountsAndOtherReceivablesNetCurrent_019ff749-bda3-76da-ab11-303fe81921e2" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_InventoryNet_019ff749-bda3-7a6d-bf9c-3a5a9ad6203c" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_InventoryNet"/>
    <link:calculationArc order="5" weight="1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_us-gaap_AssetsCurrent_019ff749-bda3-7788-8317-5643373e2eaf" xlink:to="loc_us-gaap_InventoryNet_019ff749-bda3-7a6d-bf9c-3a5a9ad6203c" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_Liabilities_019ff749-bda3-7218-a2a4-d641c31bc655" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_Liabilities"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_OtherLiabilitiesNoncurrent_019ff749-bda3-7d47-b1a4-5d9d50a62c36" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_OtherLiabilitiesNoncurrent"/>
    <link:calculationArc order="1" weight="1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_us-gaap_Liabilities_019ff749-bda3-7218-a2a4-d641c31bc655" xlink:to="loc_us-gaap_OtherLiabilitiesNoncurrent_019ff749-bda3-7d47-b1a4-5d9d50a62c36" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_zvra_DiscountAndRebateLiabilitiesNoncurrent_019ff749-bda3-7a05-8dba-ffdaea1c39aa" xlink:href="zvra-20260930.xsd#zvra_DiscountAndRebateLiabilitiesNoncurrent"/>
    <link:calculationArc order="2" weight="1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_us-gaap_Liabilities_019ff749-bda3-7218-a2a4-d641c31bc655" xlink:to="loc_zvra_DiscountAndRebateLiabilitiesNoncurrent_019ff749-bda3-7a05-8dba-ffdaea1c39aa" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_LiabilitiesCurrent_019ff749-bda3-7dec-b241-24d39e7d9130" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_LiabilitiesCurrent"/>
    <link:calculationArc order="3" weight="1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_us-gaap_Liabilities_019ff749-bda3-7218-a2a4-d641c31bc655" xlink:to="loc_us-gaap_LiabilitiesCurrent_019ff749-bda3-7dec-b241-24d39e7d9130" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_zvra_DerivativeAndWarrantLiabilityNoncurrent_019ff749-bda3-7f97-b403-64fa27e84dd7" xlink:href="zvra-20260930.xsd#zvra_DerivativeAndWarrantLiabilityNoncurrent"/>
    <link:calculationArc order="4" weight="1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_us-gaap_Liabilities_019ff749-bda3-7218-a2a4-d641c31bc655" xlink:to="loc_zvra_DerivativeAndWarrantLiabilityNoncurrent_019ff749-bda3-7f97-b403-64fa27e84dd7" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_LongTermDebtNoncurrent_019ff749-bda3-7d5d-af97-9a767fe45ff8" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_LongTermDebtNoncurrent"/>
    <link:calculationArc order="5" weight="1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_us-gaap_Liabilities_019ff749-bda3-7218-a2a4-d641c31bc655" xlink:to="loc_us-gaap_LongTermDebtNoncurrent_019ff749-bda3-7d5d-af97-9a767fe45ff8" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_OperatingLeaseLiabilityNoncurrent_019ff749-bda3-7bad-99a3-8c6e7996abab" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_OperatingLeaseLiabilityNoncurrent"/>
    <link:calculationArc order="6" weight="1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_us-gaap_Liabilities_019ff749-bda3-7218-a2a4-d641c31bc655" xlink:to="loc_us-gaap_OperatingLeaseLiabilityNoncurrent_019ff749-bda3-7bad-99a3-8c6e7996abab" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_AccruedIncomeTaxesNoncurrent_019ff749-bda3-769b-a86e-8a900600e04a" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_AccruedIncomeTaxesNoncurrent"/>
    <link:calculationArc order="7" weight="1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_us-gaap_Liabilities_019ff749-bda3-7218-a2a4-d641c31bc655" xlink:to="loc_us-gaap_AccruedIncomeTaxesNoncurrent_019ff749-bda3-769b-a86e-8a900600e04a" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_LiabilitiesAndStockholdersEquity_019ff749-bda3-77fa-8212-0587359bcf90" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_LiabilitiesAndStockholdersEquity"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_Liabilities_019ff749-bda3-76d2-bcd0-baed0c48c7f8" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_Liabilities"/>
    <link:calculationArc order="1" weight="1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_us-gaap_LiabilitiesAndStockholdersEquity_019ff749-bda3-77fa-8212-0587359bcf90" xlink:to="loc_us-gaap_Liabilities_019ff749-bda3-76d2-bcd0-baed0c48c7f8" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_CommitmentsAndContingencies_019ff749-bda3-7e82-bc5b-043ea6921801" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_CommitmentsAndContingencies"/>
    <link:calculationArc order="2" weight="1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_us-gaap_LiabilitiesAndStockholdersEquity_019ff749-bda3-77fa-8212-0587359bcf90" xlink:to="loc_us-gaap_CommitmentsAndContingencies_019ff749-bda3-7e82-bc5b-043ea6921801" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_StockholdersEquity_019ff749-bda3-7daf-9a0b-6b4af34606eb" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_StockholdersEquity"/>
    <link:calculationArc order="3" weight="1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_us-gaap_LiabilitiesAndStockholdersEquity_019ff749-bda3-77fa-8212-0587359bcf90" xlink:to="loc_us-gaap_StockholdersEquity_019ff749-bda3-7daf-9a0b-6b4af34606eb" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_StockholdersEquity_019ff749-bda3-7686-8ed8-1b600c66c067" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_StockholdersEquity"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_PreferredStockValue_019ff749-bda3-7746-9fb4-57df9b4ba813" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_PreferredStockValue"/>
    <link:calculationArc order="1" weight="1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_us-gaap_StockholdersEquity_019ff749-bda3-7686-8ed8-1b600c66c067" xlink:to="loc_us-gaap_PreferredStockValue_019ff749-bda3-7746-9fb4-57df9b4ba813" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_CommonStockValueOutstanding_019ff749-bda3-7e47-b52e-6ceb3c24076a" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_CommonStockValueOutstanding"/>
    <link:calculationArc order="2" weight="1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_us-gaap_StockholdersEquity_019ff749-bda3-7686-8ed8-1b600c66c067" xlink:to="loc_us-gaap_CommonStockValueOutstanding_019ff749-bda3-7e47-b52e-6ceb3c24076a" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_AdditionalPaidInCapitalCommonStock_019ff749-bda3-7be7-a9b0-02997049de62" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_AdditionalPaidInCapitalCommonStock"/>
    <link:calculationArc order="3" weight="1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_us-gaap_StockholdersEquity_019ff749-bda3-7686-8ed8-1b600c66c067" xlink:to="loc_us-gaap_AdditionalPaidInCapitalCommonStock_019ff749-bda3-7be7-a9b0-02997049de62" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_TreasuryStockValue_019ff749-bda3-7443-ad3b-80bdfba3f9d6" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_TreasuryStockValue"/>
    <link:calculationArc order="4" weight="-1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_us-gaap_StockholdersEquity_019ff749-bda3-7686-8ed8-1b600c66c067" xlink:to="loc_us-gaap_TreasuryStockValue_019ff749-bda3-7443-ad3b-80bdfba3f9d6" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_RetainedEarningsAccumulatedDeficit_019ff749-bda3-7718-8451-9e5f9befa237" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_RetainedEarningsAccumulatedDeficit"/>
    <link:calculationArc order="5" weight="1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_us-gaap_StockholdersEquity_019ff749-bda3-7686-8ed8-1b600c66c067" xlink:to="loc_us-gaap_RetainedEarningsAccumulatedDeficit_019ff749-bda3-7718-8451-9e5f9befa237" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_AccumulatedOtherComprehensiveIncomeLossNetOfTax_019ff749-bda3-74c6-9474-8f4a364a984e" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_AccumulatedOtherComprehensiveIncomeLossNetOfTax"/>
    <link:calculationArc order="6" weight="1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_us-gaap_StockholdersEquity_019ff749-bda3-7686-8ed8-1b600c66c067" xlink:to="loc_us-gaap_AccumulatedOtherComprehensiveIncomeLossNetOfTax_019ff749-bda3-74c6-9474-8f4a364a984e" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_Assets_019ff749-bda3-72da-8961-d0c1fb038cae" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_Assets"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_OperatingLeaseRightOfUseAsset_019ff749-bda3-7478-98ab-6c64d0dc36a4" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_OperatingLeaseRightOfUseAsset"/>
    <link:calculationArc order="1" weight="1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_us-gaap_Assets_019ff749-bda3-72da-8961-d0c1fb038cae" xlink:to="loc_us-gaap_OperatingLeaseRightOfUseAsset_019ff749-bda3-7478-98ab-6c64d0dc36a4" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_PropertyPlantAndEquipmentNet_019ff749-bda3-76e0-ba9e-16f39628639f" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_PropertyPlantAndEquipmentNet"/>
    <link:calculationArc order="2" weight="1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_us-gaap_Assets_019ff749-bda3-72da-8961-d0c1fb038cae" xlink:to="loc_us-gaap_PropertyPlantAndEquipmentNet_019ff749-bda3-76e0-ba9e-16f39628639f" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_IntangibleAssetsNetExcludingGoodwill_019ff749-bda3-7a97-bccd-ba7d068d510f" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_IntangibleAssetsNetExcludingGoodwill"/>
    <link:calculationArc order="3" weight="1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_us-gaap_Assets_019ff749-bda3-72da-8961-d0c1fb038cae" xlink:to="loc_us-gaap_IntangibleAssetsNetExcludingGoodwill_019ff749-bda3-7a97-bccd-ba7d068d510f" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_Goodwill_019ff749-bda3-73a1-98b6-8ab90d62e418" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_Goodwill"/>
    <link:calculationArc order="4" weight="1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_us-gaap_Assets_019ff749-bda3-72da-8961-d0c1fb038cae" xlink:to="loc_us-gaap_Goodwill_019ff749-bda3-73a1-98b6-8ab90d62e418" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_AssetsCurrent_019ff749-bda3-7e6b-a920-cb219ab6345c" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_AssetsCurrent"/>
    <link:calculationArc order="5" weight="1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_us-gaap_Assets_019ff749-bda3-72da-8961-d0c1fb038cae" xlink:to="loc_us-gaap_AssetsCurrent_019ff749-bda3-7e6b-a920-cb219ab6345c" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_OtherAssetsNoncurrent_019ff749-bda3-7e29-ab5c-52d4cdadb802" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_OtherAssetsNoncurrent"/>
    <link:calculationArc order="6" weight="1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_us-gaap_Assets_019ff749-bda3-72da-8961-d0c1fb038cae" xlink:to="loc_us-gaap_OtherAssetsNoncurrent_019ff749-bda3-7e29-ab5c-52d4cdadb802" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_InventoryNoncurrent_019ff749-bda3-720b-89fd-8ce48062bde4" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_InventoryNoncurrent"/>
    <link:calculationArc order="7" weight="1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_us-gaap_Assets_019ff749-bda3-72da-8961-d0c1fb038cae" xlink:to="loc_us-gaap_InventoryNoncurrent_019ff749-bda3-720b-89fd-8ce48062bde4" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_AvailableForSaleSecuritiesDebtSecuritiesNoncurrent_019ff749-bda3-7954-88de-80db5b0608fb" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_AvailableForSaleSecuritiesDebtSecuritiesNoncurrent"/>
    <link:calculationArc order="8" weight="1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_us-gaap_Assets_019ff749-bda3-72da-8961-d0c1fb038cae" xlink:to="loc_us-gaap_AvailableForSaleSecuritiesDebtSecuritiesNoncurrent_019ff749-bda3-7954-88de-80db5b0608fb" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_LiabilitiesCurrent_019ff749-bda3-7730-ab98-cae3719d621d" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_LiabilitiesCurrent"/>
    <link:loc xlink:type="locator" xlink:label="loc_zvra_DiscountAndRebateLiabilitiesCurrent_019ff749-bda3-7c4b-b765-cbca1efd87d7" xlink:href="zvra-20260930.xsd#zvra_DiscountAndRebateLiabilitiesCurrent"/>
    <link:calculationArc order="1" weight="1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_us-gaap_LiabilitiesCurrent_019ff749-bda3-7730-ab98-cae3719d621d" xlink:to="loc_zvra_DiscountAndRebateLiabilitiesCurrent_019ff749-bda3-7c4b-b765-cbca1efd87d7" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_OperatingLeaseLiabilityCurrent_019ff749-bda3-74ff-8c6d-3735ce045e8f" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_OperatingLeaseLiabilityCurrent"/>
    <link:calculationArc order="2" weight="1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_us-gaap_LiabilitiesCurrent_019ff749-bda3-7730-ab98-cae3719d621d" xlink:to="loc_us-gaap_OperatingLeaseLiabilityCurrent_019ff749-bda3-74ff-8c6d-3735ce045e8f" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_OtherLiabilitiesCurrent_019ff749-bda3-7b7a-9cf6-184bede937bb" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_OtherLiabilitiesCurrent"/>
    <link:calculationArc order="3" weight="1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_us-gaap_LiabilitiesCurrent_019ff749-bda3-7730-ab98-cae3719d621d" xlink:to="loc_us-gaap_OtherLiabilitiesCurrent_019ff749-bda3-7b7a-9cf6-184bede937bb" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_AccountsPayableAndAccruedLiabilitiesCurrent_019ff749-bda3-757f-89b6-95b7d591ec8f" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_AccountsPayableAndAccruedLiabilitiesCurrent"/>
    <link:calculationArc order="4" weight="1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_us-gaap_LiabilitiesCurrent_019ff749-bda3-7730-ab98-cae3719d621d" xlink:to="loc_us-gaap_AccountsPayableAndAccruedLiabilitiesCurrent_019ff749-bda3-757f-89b6-95b7d591ec8f" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_AccruedIncomeTaxesCurrent_019ff749-bda3-7b0e-835f-09e221e2e679" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_AccruedIncomeTaxesCurrent"/>
    <link:calculationArc order="5" weight="1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_us-gaap_LiabilitiesCurrent_019ff749-bda3-7730-ab98-cae3719d621d" xlink:to="loc_us-gaap_AccruedIncomeTaxesCurrent_019ff749-bda3-7b0e-835f-09e221e2e679" xlink:type="arc"/>
  </link:calculationLink>
  <link:roleRef roleURI="http://zevra.com/role/UNAUDITEDCONDENSEDCONSOLIDATEDSTATEMENTSOFOPERATIONS" xlink:type="simple" xlink:href="zvra-20260930.xsd#UNAUDITEDCONDENSEDCONSOLIDATEDSTATEMENTSOFOPERATIONS"/>
  <link:calculationLink xlink:role="http://zevra.com/role/UNAUDITEDCONDENSEDCONSOLIDATEDSTATEMENTSOFOPERATIONS" xlink:type="extended">
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_NetIncomeLoss_019ff749-bda3-731e-99c8-95416bff4ccc" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_NetIncomeLoss"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_IncomeLossFromContinuingOperationsBeforeIncomeTaxesExtraordinaryItemsNoncontrollingInterest_019ff749-bda3-711f-b302-3ddcfe15f97f" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_IncomeLossFromContinuingOperationsBeforeIncomeTaxesExtraordinaryItemsNoncontrollingInterest"/>
    <link:calculationArc order="1" weight="1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_us-gaap_NetIncomeLoss_019ff749-bda3-731e-99c8-95416bff4ccc" xlink:to="loc_us-gaap_IncomeLossFromContinuingOperationsBeforeIncomeTaxesExtraordinaryItemsNoncontrollingInterest_019ff749-bda3-711f-b302-3ddcfe15f97f" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_IncomeTaxExpenseBenefit_019ff749-bda3-7e2b-a198-483bddf77b32" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_IncomeTaxExpenseBenefit"/>
    <link:calculationArc order="2" weight="-1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_us-gaap_NetIncomeLoss_019ff749-bda3-731e-99c8-95416bff4ccc" xlink:to="loc_us-gaap_IncomeTaxExpenseBenefit_019ff749-bda3-7e2b-a198-483bddf77b32" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_OperatingIncomeLoss_019ff749-bda3-78b3-8a6e-669582aa8059" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_OperatingIncomeLoss"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_RevenueFromContractWithCustomerIncludingAssessedTax_019ff749-bda3-70dd-8042-af49d66d1b05" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_RevenueFromContractWithCustomerIncludingAssessedTax"/>
    <link:calculationArc order="1" weight="1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_us-gaap_OperatingIncomeLoss_019ff749-bda3-78b3-8a6e-669582aa8059" xlink:to="loc_us-gaap_RevenueFromContractWithCustomerIncludingAssessedTax_019ff749-bda3-70dd-8042-af49d66d1b05" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_CostOfGoodsAndServiceExcludingDepreciationDepletionAndAmortization_019ff749-bda3-7433-a157-23b932c38d13" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_CostOfGoodsAndServiceExcludingDepreciationDepletionAndAmortization"/>
    <link:calculationArc order="2" weight="-1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_us-gaap_OperatingIncomeLoss_019ff749-bda3-78b3-8a6e-669582aa8059" xlink:to="loc_us-gaap_CostOfGoodsAndServiceExcludingDepreciationDepletionAndAmortization_019ff749-bda3-7433-a157-23b932c38d13" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_AmortizationOfIntangibleAssets_019ff749-bda3-7558-842c-e5e1e413cfb0" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_AmortizationOfIntangibleAssets"/>
    <link:calculationArc order="3" weight="-1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_us-gaap_OperatingIncomeLoss_019ff749-bda3-78b3-8a6e-669582aa8059" xlink:to="loc_us-gaap_AmortizationOfIntangibleAssets_019ff749-bda3-7558-842c-e5e1e413cfb0" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_CostsAndExpenses_019ff749-bda3-784c-876b-3f7526ef0913" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_CostsAndExpenses"/>
    <link:calculationArc order="4" weight="-1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_us-gaap_OperatingIncomeLoss_019ff749-bda3-78b3-8a6e-669582aa8059" xlink:to="loc_us-gaap_CostsAndExpenses_019ff749-bda3-784c-876b-3f7526ef0913" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ImpairmentOfIntangibleAssetsExcludingGoodwill_019ff749-bda3-7f72-b24b-59dd19d7a45c" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_ImpairmentOfIntangibleAssetsExcludingGoodwill"/>
    <link:calculationArc order="5" weight="-1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_us-gaap_OperatingIncomeLoss_019ff749-bda3-78b3-8a6e-669582aa8059" xlink:to="loc_us-gaap_ImpairmentOfIntangibleAssetsExcludingGoodwill_019ff749-bda3-7f72-b24b-59dd19d7a45c" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_zvra_GainLossOnSaleOfFutureRoyaltiesIntellectualPropertyAndOtherAssetsNet_019ff749-bda3-71ab-bab3-c5b2c91f810d" xlink:href="zvra-20260930.xsd#zvra_GainLossOnSaleOfFutureRoyaltiesIntellectualPropertyAndOtherAssetsNet"/>
    <link:calculationArc order="6" weight="1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_us-gaap_OperatingIncomeLoss_019ff749-bda3-78b3-8a6e-669582aa8059" xlink:to="loc_zvra_GainLossOnSaleOfFutureRoyaltiesIntellectualPropertyAndOtherAssetsNet_019ff749-bda3-71ab-bab3-c5b2c91f810d" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_CostsAndExpenses_019ff749-bda3-7027-a0be-fc077cff4735" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_CostsAndExpenses"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_SellingGeneralAndAdministrativeExpense_019ff749-bda3-74fe-a699-5a05caabd4b7" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_SellingGeneralAndAdministrativeExpense"/>
    <link:calculationArc order="1" weight="1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_us-gaap_CostsAndExpenses_019ff749-bda3-7027-a0be-fc077cff4735" xlink:to="loc_us-gaap_SellingGeneralAndAdministrativeExpense_019ff749-bda3-74fe-a699-5a05caabd4b7" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ResearchAndDevelopmentExpenseExcludingAcquiredInProcessCost_019ff749-bda3-756c-beb2-bfe8b06446ba" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_ResearchAndDevelopmentExpenseExcludingAcquiredInProcessCost"/>
    <link:calculationArc order="2" weight="1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_us-gaap_CostsAndExpenses_019ff749-bda3-7027-a0be-fc077cff4735" xlink:to="loc_us-gaap_ResearchAndDevelopmentExpenseExcludingAcquiredInProcessCost_019ff749-bda3-756c-beb2-bfe8b06446ba" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_IncomeLossFromContinuingOperationsBeforeIncomeTaxesExtraordinaryItemsNoncontrollingInterest_019ff749-bda3-7cd0-a761-3ea333bbfb87" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_IncomeLossFromContinuingOperationsBeforeIncomeTaxesExtraordinaryItemsNoncontrollingInterest"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_NonoperatingIncomeExpense_019ff749-bda3-7eee-8eb0-8986ac7894bc" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_NonoperatingIncomeExpense"/>
    <link:calculationArc order="1" weight="1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_us-gaap_IncomeLossFromContinuingOperationsBeforeIncomeTaxesExtraordinaryItemsNoncontrollingInterest_019ff749-bda3-7cd0-a761-3ea333bbfb87" xlink:to="loc_us-gaap_NonoperatingIncomeExpense_019ff749-bda3-7eee-8eb0-8986ac7894bc" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_OperatingIncomeLoss_019ff749-bda3-7300-bcb8-84b1e3a4b644" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_OperatingIncomeLoss"/>
    <link:calculationArc order="2" weight="1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_us-gaap_IncomeLossFromContinuingOperationsBeforeIncomeTaxesExtraordinaryItemsNoncontrollingInterest_019ff749-bda3-7cd0-a761-3ea333bbfb87" xlink:to="loc_us-gaap_OperatingIncomeLoss_019ff749-bda3-7300-bcb8-84b1e3a4b644" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_NonoperatingIncomeExpense_019ff749-bda3-7979-b053-8c500e8a8e83" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_NonoperatingIncomeExpense"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_InterestExpenseNonoperating_019ff749-bda3-7c7a-ab78-35548d539a6c" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_InterestExpenseNonoperating"/>
    <link:calculationArc order="1" weight="-1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_us-gaap_NonoperatingIncomeExpense_019ff749-bda3-7979-b053-8c500e8a8e83" xlink:to="loc_us-gaap_InterestExpenseNonoperating_019ff749-bda3-7c7a-ab78-35548d539a6c" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_zvra_FairValueAdjustmentRelatedToWarrantAndCVRLiability_019ff749-bda3-70fb-b49b-1a8b3b0fc8d8" xlink:href="zvra-20260930.xsd#zvra_FairValueAdjustmentRelatedToWarrantAndCVRLiability"/>
    <link:calculationArc order="2" weight="-1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_us-gaap_NonoperatingIncomeExpense_019ff749-bda3-7979-b053-8c500e8a8e83" xlink:to="loc_zvra_FairValueAdjustmentRelatedToWarrantAndCVRLiability_019ff749-bda3-70fb-b49b-1a8b3b0fc8d8" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_zvra_FairValueAdjustmentOfInvestments_019ff749-bda3-7b57-872a-565fff9ed2e5" xlink:href="zvra-20260930.xsd#zvra_FairValueAdjustmentOfInvestments"/>
    <link:calculationArc order="3" weight="-1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_us-gaap_NonoperatingIncomeExpense_019ff749-bda3-7979-b053-8c500e8a8e83" xlink:to="loc_zvra_FairValueAdjustmentOfInvestments_019ff749-bda3-7b57-872a-565fff9ed2e5" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_zvra_InterestAndOtherIncomeExpenseNet_019ff749-bda3-7a12-99f0-4f53d03a9552" xlink:href="zvra-20260930.xsd#zvra_InterestAndOtherIncomeExpenseNet"/>
    <link:calculationArc order="4" weight="1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_us-gaap_NonoperatingIncomeExpense_019ff749-bda3-7979-b053-8c500e8a8e83" xlink:to="loc_zvra_InterestAndOtherIncomeExpenseNet_019ff749-bda3-7a12-99f0-4f53d03a9552" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_GainsLossesOnExtinguishmentOfDebt_019ff749-bda3-7d15-b0bd-6c491a31fa29" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_GainsLossesOnExtinguishmentOfDebt"/>
    <link:calculationArc order="5" weight="1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_us-gaap_NonoperatingIncomeExpense_019ff749-bda3-7979-b053-8c500e8a8e83" xlink:to="loc_us-gaap_GainsLossesOnExtinguishmentOfDebt_019ff749-bda3-7d15-b0bd-6c491a31fa29" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_UnrealizedGainLossOnDerivatives_019ff749-bda3-783b-84a4-f61cd6408f96" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_UnrealizedGainLossOnDerivatives"/>
    <link:calculationArc order="6" weight="1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_us-gaap_NonoperatingIncomeExpense_019ff749-bda3-7979-b053-8c500e8a8e83" xlink:to="loc_us-gaap_UnrealizedGainLossOnDerivatives_019ff749-bda3-783b-84a4-f61cd6408f96" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_GainLossOnDispositionOfIntangibleAssets_019ff749-bda3-7840-87ae-f5b4bfd50eb1" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_GainLossOnDispositionOfIntangibleAssets"/>
    <link:calculationArc order="7" weight="1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_us-gaap_NonoperatingIncomeExpense_019ff749-bda3-7979-b053-8c500e8a8e83" xlink:to="loc_us-gaap_GainLossOnDispositionOfIntangibleAssets_019ff749-bda3-7840-87ae-f5b4bfd50eb1" xlink:type="arc"/>
  </link:calculationLink>
  <link:roleRef roleURI="http://zevra.com/role/UNAUDITEDCONDENSEDCONSOLIDATEDSTATEMENTSOFCOMPREHENSIVEINCOMELOSS" xlink:type="simple" xlink:href="zvra-20260930.xsd#UNAUDITEDCONDENSEDCONSOLIDATEDSTATEMENTSOFCOMPREHENSIVEINCOMELOSS"/>
  <link:calculationLink xlink:role="http://zevra.com/role/UNAUDITEDCONDENSEDCONSOLIDATEDSTATEMENTSOFCOMPREHENSIVEINCOMELOSS" xlink:type="extended">
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ComprehensiveIncomeNetOfTax_019ff749-bda3-7583-b153-03df2484aa3b" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_ComprehensiveIncomeNetOfTax"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_NetIncomeLoss_019ff749-bda3-7c37-8edb-4cb7103104a2" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_NetIncomeLoss"/>
    <link:calculationArc order="1" weight="1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_us-gaap_ComprehensiveIncomeNetOfTax_019ff749-bda3-7583-b153-03df2484aa3b" xlink:to="loc_us-gaap_NetIncomeLoss_019ff749-bda3-7c37-8edb-4cb7103104a2" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_OtherComprehensiveIncomeLossNetOfTaxPortionAttributableToParent_019ff749-bda3-750c-9c7c-597bbb2d5051" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_OtherComprehensiveIncomeLossNetOfTaxPortionAttributableToParent"/>
    <link:calculationArc order="2" weight="1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_us-gaap_ComprehensiveIncomeNetOfTax_019ff749-bda3-7583-b153-03df2484aa3b" xlink:to="loc_us-gaap_OtherComprehensiveIncomeLossNetOfTaxPortionAttributableToParent_019ff749-bda3-750c-9c7c-597bbb2d5051" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_OtherComprehensiveIncomeLossNetOfTaxPortionAttributableToParent_019ff749-bda3-7704-8206-3961aa15e96b" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_OtherComprehensiveIncomeLossNetOfTaxPortionAttributableToParent"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_OtherComprehensiveIncomeForeignCurrencyTransactionAndTranslationGainLossArisingDuringPeriodNetOfTax_019ff749-bda3-76fb-b60d-bf8c65da6c6d" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_OtherComprehensiveIncomeForeignCurrencyTransactionAndTranslationGainLossArisingDuringPeriodNetOfTax"/>
    <link:calculationArc order="1" weight="1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_us-gaap_OtherComprehensiveIncomeLossNetOfTaxPortionAttributableToParent_019ff749-bda3-7704-8206-3961aa15e96b" xlink:to="loc_us-gaap_OtherComprehensiveIncomeForeignCurrencyTransactionAndTranslationGainLossArisingDuringPeriodNetOfTax_019ff749-bda3-76fb-b60d-bf8c65da6c6d" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_OtherComprehensiveIncomeLossAvailableForSaleSecuritiesAdjustmentNetOfTax_019ff749-bda3-7a5e-9187-be887e25cfe9" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_OtherComprehensiveIncomeLossAvailableForSaleSecuritiesAdjustmentNetOfTax"/>
    <link:calculationArc order="2" weight="1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_us-gaap_OtherComprehensiveIncomeLossNetOfTaxPortionAttributableToParent_019ff749-bda3-7704-8206-3961aa15e96b" xlink:to="loc_us-gaap_OtherComprehensiveIncomeLossAvailableForSaleSecuritiesAdjustmentNetOfTax_019ff749-bda3-7a5e-9187-be887e25cfe9" xlink:type="arc"/>
  </link:calculationLink>
  <link:roleRef roleURI="http://zevra.com/role/UNAUDITEDCONDENSEDCONSOLIDATEDSTATEMENTSOFCASHFLOWS" xlink:type="simple" xlink:href="zvra-20260930.xsd#UNAUDITEDCONDENSEDCONSOLIDATEDSTATEMENTSOFCASHFLOWS"/>
  <link:calculationLink xlink:role="http://zevra.com/role/UNAUDITEDCONDENSEDCONSOLIDATEDSTATEMENTSOFCASHFLOWS" xlink:type="extended">
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_CashCashEquivalentsRestrictedCashAndRestrictedCashEquivalentsPeriodIncreaseDecreaseIncludingExchangeRateEffect_019ff749-bda3-7d47-835f-1e8e05fb9791" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_CashCashEquivalentsRestrictedCashAndRestrictedCashEquivalentsPeriodIncreaseDecreaseIncludingExchangeRateEffect"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_NetCashProvidedByUsedInOperatingActivities_019ff749-bda3-7ffd-82f1-c8f70dcf156f" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_NetCashProvidedByUsedInOperatingActivities"/>
    <link:calculationArc order="1" weight="1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_us-gaap_CashCashEquivalentsRestrictedCashAndRestrictedCashEquivalentsPeriodIncreaseDecreaseIncludingExchangeRateEffect_019ff749-bda3-7d47-835f-1e8e05fb9791" xlink:to="loc_us-gaap_NetCashProvidedByUsedInOperatingActivities_019ff749-bda3-7ffd-82f1-c8f70dcf156f" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_EffectOfExchangeRateOnCashCashEquivalentsRestrictedCashAndRestrictedCashEquivalentsIncludingDisposalGroupAndDiscontinuedOperations_019ff749-bda3-7116-80ce-bbe2f87d786e" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_EffectOfExchangeRateOnCashCashEquivalentsRestrictedCashAndRestrictedCashEquivalentsIncludingDisposalGroupAndDiscontinuedOperations"/>
    <link:calculationArc order="2" weight="1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_us-gaap_CashCashEquivalentsRestrictedCashAndRestrictedCashEquivalentsPeriodIncreaseDecreaseIncludingExchangeRateEffect_019ff749-bda3-7d47-835f-1e8e05fb9791" xlink:to="loc_us-gaap_EffectOfExchangeRateOnCashCashEquivalentsRestrictedCashAndRestrictedCashEquivalentsIncludingDisposalGroupAndDiscontinuedOperations_019ff749-bda3-7116-80ce-bbe2f87d786e" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_NetCashProvidedByUsedInFinancingActivities_019ff749-bda3-7dae-9692-9cc4824fe63f" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_NetCashProvidedByUsedInFinancingActivities"/>
    <link:calculationArc order="3" weight="1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_us-gaap_CashCashEquivalentsRestrictedCashAndRestrictedCashEquivalentsPeriodIncreaseDecreaseIncludingExchangeRateEffect_019ff749-bda3-7d47-835f-1e8e05fb9791" xlink:to="loc_us-gaap_NetCashProvidedByUsedInFinancingActivities_019ff749-bda3-7dae-9692-9cc4824fe63f" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_NetCashProvidedByUsedInInvestingActivities_019ff749-bda3-7898-b336-a031b1e9ce47" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_NetCashProvidedByUsedInInvestingActivities"/>
    <link:calculationArc order="4" weight="1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_us-gaap_CashCashEquivalentsRestrictedCashAndRestrictedCashEquivalentsPeriodIncreaseDecreaseIncludingExchangeRateEffect_019ff749-bda3-7d47-835f-1e8e05fb9791" xlink:to="loc_us-gaap_NetCashProvidedByUsedInInvestingActivities_019ff749-bda3-7898-b336-a031b1e9ce47" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_NetCashProvidedByUsedInInvestingActivities_019ff749-bda3-71e5-ac76-9d59b19ad6ee" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_NetCashProvidedByUsedInInvestingActivities"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ProceedsFromSaleOfIntangibleAssets_019ff749-bda3-7e03-b006-50b8a7753da5" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_ProceedsFromSaleOfIntangibleAssets"/>
    <link:calculationArc order="1" weight="1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_us-gaap_NetCashProvidedByUsedInInvestingActivities_019ff749-bda3-71e5-ac76-9d59b19ad6ee" xlink:to="loc_us-gaap_ProceedsFromSaleOfIntangibleAssets_019ff749-bda3-7e03-b006-50b8a7753da5" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_PaymentsToAcquirePropertyPlantAndEquipment_019ff749-bda3-767f-a298-6ac6a701c136" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_PaymentsToAcquirePropertyPlantAndEquipment"/>
    <link:calculationArc order="2" weight="-1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_us-gaap_NetCashProvidedByUsedInInvestingActivities_019ff749-bda3-71e5-ac76-9d59b19ad6ee" xlink:to="loc_us-gaap_PaymentsToAcquirePropertyPlantAndEquipment_019ff749-bda3-767f-a298-6ac6a701c136" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ProceedsFromSaleOfPropertyPlantAndEquipment_019ff749-bda3-7d8b-9062-1d0ed745c4ef" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_ProceedsFromSaleOfPropertyPlantAndEquipment"/>
    <link:calculationArc order="3" weight="1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_us-gaap_NetCashProvidedByUsedInInvestingActivities_019ff749-bda3-71e5-ac76-9d59b19ad6ee" xlink:to="loc_us-gaap_ProceedsFromSaleOfPropertyPlantAndEquipment_019ff749-bda3-7d8b-9062-1d0ed745c4ef" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_PaymentsToAcquireOtherInvestments_019ff749-bda3-7e89-beb3-6936ef916274" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_PaymentsToAcquireOtherInvestments"/>
    <link:calculationArc order="4" weight="-1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_us-gaap_NetCashProvidedByUsedInInvestingActivities_019ff749-bda3-71e5-ac76-9d59b19ad6ee" xlink:to="loc_us-gaap_PaymentsToAcquireOtherInvestments_019ff749-bda3-7e89-beb3-6936ef916274" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ProceedsFromSaleMaturityAndCollectionsOfInvestments_019ff749-bda3-73be-90fa-d86d89c5ecb7" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_ProceedsFromSaleMaturityAndCollectionsOfInvestments"/>
    <link:calculationArc order="5" weight="1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_us-gaap_NetCashProvidedByUsedInInvestingActivities_019ff749-bda3-71e5-ac76-9d59b19ad6ee" xlink:to="loc_us-gaap_ProceedsFromSaleMaturityAndCollectionsOfInvestments_019ff749-bda3-73be-90fa-d86d89c5ecb7" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_zvra_ProceedsFromSaleOfPriorityReviewVoucher_01a03304-5e12-7a8a-b821-eede44913dec" xlink:href="zvra-20260930.xsd#zvra_ProceedsFromSaleOfPriorityReviewVoucher"/>
    <link:calculationArc order="6" weight="1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_us-gaap_NetCashProvidedByUsedInInvestingActivities_019ff749-bda3-71e5-ac76-9d59b19ad6ee" xlink:to="loc_zvra_ProceedsFromSaleOfPriorityReviewVoucher_01a03304-5e12-7a8a-b821-eede44913dec" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_NetCashProvidedByUsedInOperatingActivities_019ff749-bda3-756e-a326-ed00851c6ed4" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_NetCashProvidedByUsedInOperatingActivities"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_NetIncomeLoss_019ff749-bda3-7d4c-93a6-6c04e044903d" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_NetIncomeLoss"/>
    <link:calculationArc order="1" weight="1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_us-gaap_NetCashProvidedByUsedInOperatingActivities_019ff749-bda3-756e-a326-ed00851c6ed4" xlink:to="loc_us-gaap_NetIncomeLoss_019ff749-bda3-7d4c-93a6-6c04e044903d" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ShareBasedCompensation_019ff749-bda3-742f-a673-f75021b903e5" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_ShareBasedCompensation"/>
    <link:calculationArc order="2" weight="1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_us-gaap_NetCashProvidedByUsedInOperatingActivities_019ff749-bda3-756e-a326-ed00851c6ed4" xlink:to="loc_us-gaap_ShareBasedCompensation_019ff749-bda3-742f-a673-f75021b903e5" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_InventoryWriteDown_019ff749-bda3-71cc-99ad-2a6d8fc8bab3" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_InventoryWriteDown"/>
    <link:calculationArc order="3" weight="1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_us-gaap_NetCashProvidedByUsedInOperatingActivities_019ff749-bda3-756e-a326-ed00851c6ed4" xlink:to="loc_us-gaap_InventoryWriteDown_019ff749-bda3-71cc-99ad-2a6d8fc8bab3" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_zvra_IncomeTaxExpenseBenefitNoncashAdjustment_019ff749-bda3-79b3-a5e5-a24603c4b818" xlink:href="zvra-20260930.xsd#zvra_IncomeTaxExpenseBenefitNoncashAdjustment"/>
    <link:calculationArc order="4" weight="1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_us-gaap_NetCashProvidedByUsedInOperatingActivities_019ff749-bda3-756e-a326-ed00851c6ed4" xlink:to="loc_zvra_IncomeTaxExpenseBenefitNoncashAdjustment_019ff749-bda3-79b3-a5e5-a24603c4b818" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_DepreciationDepletionAndAmortization_019ff749-bda3-7e03-bfb4-9106c06287b6" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_DepreciationDepletionAndAmortization"/>
    <link:calculationArc order="5" weight="1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_us-gaap_NetCashProvidedByUsedInOperatingActivities_019ff749-bda3-756e-a326-ed00851c6ed4" xlink:to="loc_us-gaap_DepreciationDepletionAndAmortization_019ff749-bda3-7e03-bfb4-9106c06287b6" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_OtherNoncashExpense_019ff749-bda3-7f46-9dd9-a56312902cbe" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_OtherNoncashExpense"/>
    <link:calculationArc order="6" weight="1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_us-gaap_NetCashProvidedByUsedInOperatingActivities_019ff749-bda3-756e-a326-ed00851c6ed4" xlink:to="loc_us-gaap_OtherNoncashExpense_019ff749-bda3-7f46-9dd9-a56312902cbe" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_zvra_FairValueAdjustmentRelatedToWarrantAndCVRLiability_019ff749-bda3-73fa-82c7-82722795d748" xlink:href="zvra-20260930.xsd#zvra_FairValueAdjustmentRelatedToWarrantAndCVRLiability"/>
    <link:calculationArc order="7" weight="1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_us-gaap_NetCashProvidedByUsedInOperatingActivities_019ff749-bda3-756e-a326-ed00851c6ed4" xlink:to="loc_zvra_FairValueAdjustmentRelatedToWarrantAndCVRLiability_019ff749-bda3-73fa-82c7-82722795d748" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_AccretionAmortizationOfDiscountsAndPremiumsInvestments_019ff749-bda3-7016-aa21-104394d7b35c" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_AccretionAmortizationOfDiscountsAndPremiumsInvestments"/>
    <link:calculationArc order="8" weight="-1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_us-gaap_NetCashProvidedByUsedInOperatingActivities_019ff749-bda3-756e-a326-ed00851c6ed4" xlink:to="loc_us-gaap_AccretionAmortizationOfDiscountsAndPremiumsInvestments_019ff749-bda3-7016-aa21-104394d7b35c" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_zvra_FairValueAdjustmentOfInvestments_019ff749-bda3-7dbe-ab4e-f77049355c29" xlink:href="zvra-20260930.xsd#zvra_FairValueAdjustmentOfInvestments"/>
    <link:calculationArc order="9" weight="1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_us-gaap_NetCashProvidedByUsedInOperatingActivities_019ff749-bda3-756e-a326-ed00851c6ed4" xlink:to="loc_zvra_FairValueAdjustmentOfInvestments_019ff749-bda3-7dbe-ab4e-f77049355c29" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_GainsLossesOnExtinguishmentOfDebt_019ff749-bda3-72bc-b239-f033596b1094" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_GainsLossesOnExtinguishmentOfDebt"/>
    <link:calculationArc order="10" weight="-1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_us-gaap_NetCashProvidedByUsedInOperatingActivities_019ff749-bda3-756e-a326-ed00851c6ed4" xlink:to="loc_us-gaap_GainsLossesOnExtinguishmentOfDebt_019ff749-bda3-72bc-b239-f033596b1094" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_zvra_FairValueAdjustmentRelatedToDerivativeInstrument_019ff749-bda3-7bbc-89b0-491c1945329f" xlink:href="zvra-20260930.xsd#zvra_FairValueAdjustmentRelatedToDerivativeInstrument"/>
    <link:calculationArc order="11" weight="-1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_us-gaap_NetCashProvidedByUsedInOperatingActivities_019ff749-bda3-756e-a326-ed00851c6ed4" xlink:to="loc_zvra_FairValueAdjustmentRelatedToDerivativeInstrument_019ff749-bda3-7bbc-89b0-491c1945329f" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_zvra_CashPaidToSettleDerivativeInstrumentAndPayoffPremium_019ff749-bda3-7876-a8cd-f01747cfac83" xlink:href="zvra-20260930.xsd#zvra_CashPaidToSettleDerivativeInstrumentAndPayoffPremium"/>
    <link:calculationArc order="12" weight="-1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_us-gaap_NetCashProvidedByUsedInOperatingActivities_019ff749-bda3-756e-a326-ed00851c6ed4" xlink:to="loc_zvra_CashPaidToSettleDerivativeInstrumentAndPayoffPremium_019ff749-bda3-7876-a8cd-f01747cfac83" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_zvra_PaymentOfPaidInKindInterest_019ff749-bda3-7caa-ab17-0a2b250914c5" xlink:href="zvra-20260930.xsd#zvra_PaymentOfPaidInKindInterest"/>
    <link:calculationArc order="13" weight="-1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_us-gaap_NetCashProvidedByUsedInOperatingActivities_019ff749-bda3-756e-a326-ed00851c6ed4" xlink:to="loc_zvra_PaymentOfPaidInKindInterest_019ff749-bda3-7caa-ab17-0a2b250914c5" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_GainLossOnDispositionOfIntangibleAssets_019ff749-bda3-763d-b725-f6369f79bcce" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_GainLossOnDispositionOfIntangibleAssets"/>
    <link:calculationArc order="14" weight="-1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_us-gaap_NetCashProvidedByUsedInOperatingActivities_019ff749-bda3-756e-a326-ed00851c6ed4" xlink:to="loc_us-gaap_GainLossOnDispositionOfIntangibleAssets_019ff749-bda3-763d-b725-f6369f79bcce" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_zvra_ConsultingFeesPaidInCommonStock_019ff749-bda3-7b1e-bfe8-94d959f520b0" xlink:href="zvra-20260930.xsd#zvra_ConsultingFeesPaidInCommonStock"/>
    <link:calculationArc order="15" weight="1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_us-gaap_NetCashProvidedByUsedInOperatingActivities_019ff749-bda3-756e-a326-ed00851c6ed4" xlink:to="loc_zvra_ConsultingFeesPaidInCommonStock_019ff749-bda3-7b1e-bfe8-94d959f520b0" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ForeignCurrencyTransactionGainLossBeforeTax_019ff749-bda3-7064-92ea-9617a7d77e26" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_ForeignCurrencyTransactionGainLossBeforeTax"/>
    <link:calculationArc order="16" weight="-1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_us-gaap_NetCashProvidedByUsedInOperatingActivities_019ff749-bda3-756e-a326-ed00851c6ed4" xlink:to="loc_us-gaap_ForeignCurrencyTransactionGainLossBeforeTax_019ff749-bda3-7064-92ea-9617a7d77e26" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_IncreaseDecreaseInAccountsAndOtherReceivables_019ff749-bda3-75b8-a032-a838a4ad6d2e" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_IncreaseDecreaseInAccountsAndOtherReceivables"/>
    <link:calculationArc order="17" weight="-1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_us-gaap_NetCashProvidedByUsedInOperatingActivities_019ff749-bda3-756e-a326-ed00851c6ed4" xlink:to="loc_us-gaap_IncreaseDecreaseInAccountsAndOtherReceivables_019ff749-bda3-75b8-a032-a838a4ad6d2e" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_IncreaseDecreaseInPrepaidDeferredExpenseAndOtherAssets_019ff749-bda3-78cf-aea2-bdbc7c942747" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_IncreaseDecreaseInPrepaidDeferredExpenseAndOtherAssets"/>
    <link:calculationArc order="18" weight="-1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_us-gaap_NetCashProvidedByUsedInOperatingActivities_019ff749-bda3-756e-a326-ed00851c6ed4" xlink:to="loc_us-gaap_IncreaseDecreaseInPrepaidDeferredExpenseAndOtherAssets_019ff749-bda3-78cf-aea2-bdbc7c942747" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_IncreaseDecreaseInInventories_019ff749-bda3-7758-91ba-125980a47b72" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_IncreaseDecreaseInInventories"/>
    <link:calculationArc order="19" weight="-1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_us-gaap_NetCashProvidedByUsedInOperatingActivities_019ff749-bda3-756e-a326-ed00851c6ed4" xlink:to="loc_us-gaap_IncreaseDecreaseInInventories_019ff749-bda3-7758-91ba-125980a47b72" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_zvra_IncreaseDecreaseInOperatingLeaseRightOfUseAsset_019ff749-bda3-71d2-ad72-db1100a55e55" xlink:href="zvra-20260930.xsd#zvra_IncreaseDecreaseInOperatingLeaseRightOfUseAsset"/>
    <link:calculationArc order="20" weight="-1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_us-gaap_NetCashProvidedByUsedInOperatingActivities_019ff749-bda3-756e-a326-ed00851c6ed4" xlink:to="loc_zvra_IncreaseDecreaseInOperatingLeaseRightOfUseAsset_019ff749-bda3-71d2-ad72-db1100a55e55" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_IncreaseDecreaseInAccountsPayableAndAccruedLiabilities_019ff749-bda3-798a-b861-bfe7882d4858" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_IncreaseDecreaseInAccountsPayableAndAccruedLiabilities"/>
    <link:calculationArc order="21" weight="1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_us-gaap_NetCashProvidedByUsedInOperatingActivities_019ff749-bda3-756e-a326-ed00851c6ed4" xlink:to="loc_us-gaap_IncreaseDecreaseInAccountsPayableAndAccruedLiabilities_019ff749-bda3-798a-b861-bfe7882d4858" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_zvra_DiscountAndRebateLiabilities_019ff749-bda3-7c5b-abe9-0717c6647a28" xlink:href="zvra-20260930.xsd#zvra_DiscountAndRebateLiabilities"/>
    <link:calculationArc order="22" weight="1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_us-gaap_NetCashProvidedByUsedInOperatingActivities_019ff749-bda3-756e-a326-ed00851c6ed4" xlink:to="loc_zvra_DiscountAndRebateLiabilities_019ff749-bda3-7c5b-abe9-0717c6647a28" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_IncreaseDecreaseInOperatingLeaseLiability_019ff749-bda3-7c70-b9eb-24b3bbb3578c" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_IncreaseDecreaseInOperatingLeaseLiability"/>
    <link:calculationArc order="23" weight="1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_us-gaap_NetCashProvidedByUsedInOperatingActivities_019ff749-bda3-756e-a326-ed00851c6ed4" xlink:to="loc_us-gaap_IncreaseDecreaseInOperatingLeaseLiability_019ff749-bda3-7c70-b9eb-24b3bbb3578c" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_IncreaseDecreaseInOtherNoncurrentLiabilities_019ff749-bda3-7715-b157-173b8be44684" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_IncreaseDecreaseInOtherNoncurrentLiabilities"/>
    <link:calculationArc order="24" weight="1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_us-gaap_NetCashProvidedByUsedInOperatingActivities_019ff749-bda3-756e-a326-ed00851c6ed4" xlink:to="loc_us-gaap_IncreaseDecreaseInOtherNoncurrentLiabilities_019ff749-bda3-7715-b157-173b8be44684" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_IncreaseDecreaseInRoyaltiesPayable_019ff749-bda3-7c77-877e-e522631e8d17" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_IncreaseDecreaseInRoyaltiesPayable"/>
    <link:calculationArc order="25" weight="1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_us-gaap_NetCashProvidedByUsedInOperatingActivities_019ff749-bda3-756e-a326-ed00851c6ed4" xlink:to="loc_us-gaap_IncreaseDecreaseInRoyaltiesPayable_019ff749-bda3-7c77-877e-e522631e8d17" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ImpairmentOfIntangibleAssetsExcludingGoodwill_019ff749-bda3-793f-9224-94e389c70d03" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_ImpairmentOfIntangibleAssetsExcludingGoodwill"/>
    <link:calculationArc order="26" weight="1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_us-gaap_NetCashProvidedByUsedInOperatingActivities_019ff749-bda3-756e-a326-ed00851c6ed4" xlink:to="loc_us-gaap_ImpairmentOfIntangibleAssetsExcludingGoodwill_019ff749-bda3-793f-9224-94e389c70d03" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_zvra_GainLossOnSaleOfFutureRoyaltiesIntellectualPropertyAndOtherAssetsNet_019ff749-bda3-768f-b34c-a8f256d1bcc4" xlink:href="zvra-20260930.xsd#zvra_GainLossOnSaleOfFutureRoyaltiesIntellectualPropertyAndOtherAssetsNet"/>
    <link:calculationArc order="27" weight="-1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_us-gaap_NetCashProvidedByUsedInOperatingActivities_019ff749-bda3-756e-a326-ed00851c6ed4" xlink:to="loc_zvra_GainLossOnSaleOfFutureRoyaltiesIntellectualPropertyAndOtherAssetsNet_019ff749-bda3-768f-b34c-a8f256d1bcc4" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_OperatingLeaseRightOfUseAssetAmortizationExpense_019ff749-bda3-7f47-9400-2f2dc952d6db" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_OperatingLeaseRightOfUseAssetAmortizationExpense"/>
    <link:calculationArc order="28" weight="1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_us-gaap_NetCashProvidedByUsedInOperatingActivities_019ff749-bda3-756e-a326-ed00851c6ed4" xlink:to="loc_us-gaap_OperatingLeaseRightOfUseAssetAmortizationExpense_019ff749-bda3-7f47-9400-2f2dc952d6db" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_IncreaseDecreaseInOtherNoncurrentAssets_019ff749-bda3-7c1a-bad4-18effe41ab7c" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_IncreaseDecreaseInOtherNoncurrentAssets"/>
    <link:calculationArc order="29" weight="-1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_us-gaap_NetCashProvidedByUsedInOperatingActivities_019ff749-bda3-756e-a326-ed00851c6ed4" xlink:to="loc_us-gaap_IncreaseDecreaseInOtherNoncurrentAssets_019ff749-bda3-7c1a-bad4-18effe41ab7c" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_NetCashProvidedByUsedInFinancingActivities_019ff749-bda3-7826-bd13-8a1e6f918120" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_NetCashProvidedByUsedInFinancingActivities"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_RepaymentsOfDebt_019ff749-bda3-76de-918a-0d12e185e81b" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_RepaymentsOfDebt"/>
    <link:calculationArc order="1" weight="-1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_us-gaap_NetCashProvidedByUsedInFinancingActivities_019ff749-bda3-7826-bd13-8a1e6f918120" xlink:to="loc_us-gaap_RepaymentsOfDebt_019ff749-bda3-76de-918a-0d12e185e81b" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ProceedsFromWarrantExercises_019ff749-bda3-7d99-9d55-43ea18c0d47e" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_ProceedsFromWarrantExercises"/>
    <link:calculationArc order="2" weight="1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_us-gaap_NetCashProvidedByUsedInFinancingActivities_019ff749-bda3-7826-bd13-8a1e6f918120" xlink:to="loc_us-gaap_ProceedsFromWarrantExercises_019ff749-bda3-7d99-9d55-43ea18c0d47e" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_zvra_PaymentsOfPrincipalOnInsuranceFinancingArrangements_019ff749-bda3-7fed-baab-471a67d4c5e7" xlink:href="zvra-20260930.xsd#zvra_PaymentsOfPrincipalOnInsuranceFinancingArrangements"/>
    <link:calculationArc order="3" weight="-1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_us-gaap_NetCashProvidedByUsedInFinancingActivities_019ff749-bda3-7826-bd13-8a1e6f918120" xlink:to="loc_zvra_PaymentsOfPrincipalOnInsuranceFinancingArrangements_019ff749-bda3-7fed-baab-471a67d4c5e7" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_PaymentsRelatedToTaxWithholdingForShareBasedCompensation_019ff749-bda3-75c0-9b48-ce88e50ce099" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_PaymentsRelatedToTaxWithholdingForShareBasedCompensation"/>
    <link:calculationArc order="4" weight="-1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_us-gaap_NetCashProvidedByUsedInFinancingActivities_019ff749-bda3-7826-bd13-8a1e6f918120" xlink:to="loc_us-gaap_PaymentsRelatedToTaxWithholdingForShareBasedCompensation_019ff749-bda3-75c0-9b48-ce88e50ce099" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ProceedsFromIssuanceOfSharesUnderIncentiveAndShareBasedCompensationPlansIncludingStockOptions_019ff749-bda3-7fd2-801e-179eee376235" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_ProceedsFromIssuanceOfSharesUnderIncentiveAndShareBasedCompensationPlansIncludingStockOptions"/>
    <link:calculationArc order="5" weight="1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_us-gaap_NetCashProvidedByUsedInFinancingActivities_019ff749-bda3-7826-bd13-8a1e6f918120" xlink:to="loc_us-gaap_ProceedsFromIssuanceOfSharesUnderIncentiveAndShareBasedCompensationPlansIncludingStockOptions_019ff749-bda3-7fd2-801e-179eee376235" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ProceedsFromRepaymentOfLoansByEmployeeStockOwnershipPlans_019ff749-bda3-7560-b54a-5019d08217e9" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_ProceedsFromRepaymentOfLoansByEmployeeStockOwnershipPlans"/>
    <link:calculationArc order="6" weight="1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_us-gaap_NetCashProvidedByUsedInFinancingActivities_019ff749-bda3-7826-bd13-8a1e6f918120" xlink:to="loc_us-gaap_ProceedsFromRepaymentOfLoansByEmployeeStockOwnershipPlans_019ff749-bda3-7560-b54a-5019d08217e9" xlink:type="arc"/>
  </link:calculationLink>
  <link:roleRef roleURI="http://zevra.com/role/SegmentInformationSegmentReportingInformationbySegmentDetails" xlink:type="simple" xlink:href="zvra-20260930.xsd#SegmentInformationSegmentReportingInformationbySegmentDetails"/>
  <link:calculationLink xlink:role="http://zevra.com/role/SegmentInformationSegmentReportingInformationbySegmentDetails" xlink:type="extended">
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_NetIncomeLoss_019ff749-bda4-7c39-ba1c-26629748410a" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_NetIncomeLoss"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_RevenueFromContractWithCustomerIncludingAssessedTax_019ff749-bda4-752e-abbf-2851553f6362" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_RevenueFromContractWithCustomerIncludingAssessedTax"/>
    <link:calculationArc order="1" weight="1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_us-gaap_NetIncomeLoss_019ff749-bda4-7c39-ba1c-26629748410a" xlink:to="loc_us-gaap_RevenueFromContractWithCustomerIncludingAssessedTax_019ff749-bda4-752e-abbf-2851553f6362" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ResearchAndDevelopmentExpenseExcludingAcquiredInProcessCost_019ff749-bda4-7cc1-8c4b-a16100e1c73c" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_ResearchAndDevelopmentExpenseExcludingAcquiredInProcessCost"/>
    <link:calculationArc order="2" weight="-1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_us-gaap_NetIncomeLoss_019ff749-bda4-7c39-ba1c-26629748410a" xlink:to="loc_us-gaap_ResearchAndDevelopmentExpenseExcludingAcquiredInProcessCost_019ff749-bda4-7cc1-8c4b-a16100e1c73c" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_SellingGeneralAndAdministrativeExpense_019ff749-bda4-7594-94f5-0ea05a0229bf" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_SellingGeneralAndAdministrativeExpense"/>
    <link:calculationArc order="3" weight="-1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_us-gaap_NetIncomeLoss_019ff749-bda4-7c39-ba1c-26629748410a" xlink:to="loc_us-gaap_SellingGeneralAndAdministrativeExpense_019ff749-bda4-7594-94f5-0ea05a0229bf" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_IncomeTaxExpenseBenefit_019ff749-bda4-79c0-b65e-67683a44dc2d" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_IncomeTaxExpenseBenefit"/>
    <link:calculationArc order="4" weight="-1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_us-gaap_NetIncomeLoss_019ff749-bda4-7c39-ba1c-26629748410a" xlink:to="loc_us-gaap_IncomeTaxExpenseBenefit_019ff749-bda4-79c0-b65e-67683a44dc2d" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_InvestmentIncomeInterest_019ff749-bda4-7d7d-bca4-20921a3ef621" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_InvestmentIncomeInterest"/>
    <link:calculationArc order="5" weight="1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_us-gaap_NetIncomeLoss_019ff749-bda4-7c39-ba1c-26629748410a" xlink:to="loc_us-gaap_InvestmentIncomeInterest_019ff749-bda4-7d7d-bca4-20921a3ef621" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_DepreciationDepletionAndAmortization_019ff749-bda4-7792-aaa9-82ef9e53c432" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_DepreciationDepletionAndAmortization"/>
    <link:calculationArc order="6" weight="-1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_us-gaap_NetIncomeLoss_019ff749-bda4-7c39-ba1c-26629748410a" xlink:to="loc_us-gaap_DepreciationDepletionAndAmortization_019ff749-bda4-7792-aaa9-82ef9e53c432" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_InterestExpenseNonoperating_019ff749-bda4-7da3-b7d6-f644f0b5d02f" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_InterestExpenseNonoperating"/>
    <link:calculationArc order="7" weight="-1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_us-gaap_NetIncomeLoss_019ff749-bda4-7c39-ba1c-26629748410a" xlink:to="loc_us-gaap_InterestExpenseNonoperating_019ff749-bda4-7da3-b7d6-f644f0b5d02f" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_OtherNonoperatingIncomeExpense_019ff749-bda4-7c7c-bfcb-a8c60db693a8" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_OtherNonoperatingIncomeExpense"/>
    <link:calculationArc order="8" weight="1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_us-gaap_NetIncomeLoss_019ff749-bda4-7c39-ba1c-26629748410a" xlink:to="loc_us-gaap_OtherNonoperatingIncomeExpense_019ff749-bda4-7c7c-bfcb-a8c60db693a8" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ImpairmentOfIntangibleAssetsFinitelived_019ff749-bda4-72a5-aefe-79bdc513573b" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_ImpairmentOfIntangibleAssetsFinitelived"/>
    <link:calculationArc order="9" weight="-1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_us-gaap_NetIncomeLoss_019ff749-bda4-7c39-ba1c-26629748410a" xlink:to="loc_us-gaap_ImpairmentOfIntangibleAssetsFinitelived_019ff749-bda4-72a5-aefe-79bdc513573b" xlink:type="arc"/>
  </link:calculationLink>
  <link:roleRef roleURI="http://zevra.com/role/InventoriesDetails" xlink:type="simple" xlink:href="zvra-20260930.xsd#InventoriesDetails"/>
  <link:calculationLink xlink:role="http://zevra.com/role/InventoriesDetails" xlink:type="extended">
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_InventoryGross_019ff749-bda4-7683-8c82-a4e7c75c57c4" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_InventoryGross"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_InventoryRawMaterials_019ff749-bda4-7b9d-9324-564af481528d" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_InventoryRawMaterials"/>
    <link:calculationArc order="1" weight="1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_us-gaap_InventoryGross_019ff749-bda4-7683-8c82-a4e7c75c57c4" xlink:to="loc_us-gaap_InventoryRawMaterials_019ff749-bda4-7b9d-9324-564af481528d" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_InventoryWorkInProcess_019ff749-bda4-7da5-b475-0114361cda33" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_InventoryWorkInProcess"/>
    <link:calculationArc order="2" weight="1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_us-gaap_InventoryGross_019ff749-bda4-7683-8c82-a4e7c75c57c4" xlink:to="loc_us-gaap_InventoryWorkInProcess_019ff749-bda4-7da5-b475-0114361cda33" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_InventoryFinishedGoods_019ff749-bda4-72d6-8bbb-b4fe952863cf" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_InventoryFinishedGoods"/>
    <link:calculationArc order="3" weight="1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_us-gaap_InventoryGross_019ff749-bda4-7683-8c82-a4e7c75c57c4" xlink:to="loc_us-gaap_InventoryFinishedGoods_019ff749-bda4-72d6-8bbb-b4fe952863cf" xlink:type="arc"/>
  </link:calculationLink>
  <link:roleRef roleURI="http://zevra.com/role/DebtObligationsScheduleofLongTermDebtDetails" xlink:type="simple" xlink:href="zvra-20260930.xsd#DebtObligationsScheduleofLongTermDebtDetails"/>
  <link:calculationLink xlink:role="http://zevra.com/role/DebtObligationsScheduleofLongTermDebtDetails" xlink:type="extended">
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_LongTermDebt_019ff749-bda4-7958-a459-d972a1915565" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_LongTermDebt"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_DebtInstrumentCarryingAmount_019ff749-bda4-7f11-ae0a-7b2325594646" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_DebtInstrumentCarryingAmount"/>
    <link:calculationArc order="1" weight="1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_us-gaap_LongTermDebt_019ff749-bda4-7958-a459-d972a1915565" xlink:to="loc_us-gaap_DebtInstrumentCarryingAmount_019ff749-bda4-7f11-ae0a-7b2325594646" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_DeferredFinanceCostsNet_019ff749-bda4-73c7-b385-4e16a13b0333" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_DeferredFinanceCostsNet"/>
    <link:calculationArc order="2" weight="-1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_us-gaap_LongTermDebt_019ff749-bda4-7958-a459-d972a1915565" xlink:to="loc_us-gaap_DeferredFinanceCostsNet_019ff749-bda4-73c7-b385-4e16a13b0333" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_DebtInstrumentUnamortizedDiscountPremiumNet_019ff749-bda4-7a6f-beb2-6b1ed82217fd" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_DebtInstrumentUnamortizedDiscountPremiumNet"/>
    <link:calculationArc order="3" weight="-1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_us-gaap_LongTermDebt_019ff749-bda4-7958-a459-d972a1915565" xlink:to="loc_us-gaap_DebtInstrumentUnamortizedDiscountPremiumNet_019ff749-bda4-7a6f-beb2-6b1ed82217fd" xlink:type="arc"/>
  </link:calculationLink>
  <link:roleRef roleURI="http://zevra.com/role/NetIncomeLossPerShareScheduleofNetIncomeLossPerShareBasicandDilutedDetails" xlink:type="simple" xlink:href="zvra-20260930.xsd#NetIncomeLossPerShareScheduleofNetIncomeLossPerShareBasicandDilutedDetails"/>
  <link:calculationLink xlink:role="http://zevra.com/role/NetIncomeLossPerShareScheduleofNetIncomeLossPerShareBasicandDilutedDetails" xlink:type="extended">
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_NetIncomeLossAvailableToCommonStockholdersBasic_019ff749-be43-7308-a2b2-d445c2f5fd71" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_NetIncomeLossAvailableToCommonStockholdersBasic"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_NetIncomeLoss_019ff749-be43-714c-8230-27c8733116d6" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_NetIncomeLoss"/>
    <link:calculationArc order="1" weight="1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_us-gaap_NetIncomeLossAvailableToCommonStockholdersBasic_019ff749-be43-7308-a2b2-d445c2f5fd71" xlink:to="loc_us-gaap_NetIncomeLoss_019ff749-be43-714c-8230-27c8733116d6" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ParticipatingSecuritiesDistributedAndUndistributedEarningsLossBasic_019ff749-be43-759e-9803-dc1faf7fd52d" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_ParticipatingSecuritiesDistributedAndUndistributedEarningsLossBasic"/>
    <link:calculationArc order="2" weight="-1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_us-gaap_NetIncomeLossAvailableToCommonStockholdersBasic_019ff749-be43-7308-a2b2-d445c2f5fd71" xlink:to="loc_us-gaap_ParticipatingSecuritiesDistributedAndUndistributedEarningsLossBasic_019ff749-be43-759e-9803-dc1faf7fd52d" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_WeightedAverageNumberOfDilutedSharesOutstanding_019ff749-be43-7e5f-95b3-06e7a9dc1d8a" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_WeightedAverageNumberOfDilutedSharesOutstanding"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_WeightedAverageNumberOfSharesOutstandingBasic_019ff749-be43-7c82-a686-425fb759e775" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_WeightedAverageNumberOfSharesOutstandingBasic"/>
    <link:calculationArc order="1" weight="1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_us-gaap_WeightedAverageNumberOfDilutedSharesOutstanding_019ff749-be43-7e5f-95b3-06e7a9dc1d8a" xlink:to="loc_us-gaap_WeightedAverageNumberOfSharesOutstandingBasic_019ff749-be43-7c82-a686-425fb759e775" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_WeightedAverageNumberDilutedSharesOutstandingAdjustment_019ff749-be43-739b-afe0-7bc6c67a6a9e" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_WeightedAverageNumberDilutedSharesOutstandingAdjustment"/>
    <link:calculationArc order="2" weight="1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_us-gaap_WeightedAverageNumberOfDilutedSharesOutstanding_019ff749-be43-7e5f-95b3-06e7a9dc1d8a" xlink:to="loc_us-gaap_WeightedAverageNumberDilutedSharesOutstandingAdjustment_019ff749-be43-739b-afe0-7bc6c67a6a9e" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_UndistributedEarningsLossAvailableToCommonShareholdersBasic_019ff749-be43-7f95-a379-06da67ce3169" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_UndistributedEarningsLossAvailableToCommonShareholdersBasic"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_NetIncomeLossAvailableToCommonStockholdersBasic_019ff749-be43-7ee0-8ffc-7fbd972771d8" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_NetIncomeLossAvailableToCommonStockholdersBasic"/>
    <link:calculationArc order="1" weight="1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_us-gaap_UndistributedEarningsLossAvailableToCommonShareholdersBasic_019ff749-be43-7f95-a379-06da67ce3169" xlink:to="loc_us-gaap_NetIncomeLossAvailableToCommonStockholdersBasic_019ff749-be43-7ee0-8ffc-7fbd972771d8" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_PreferredStockDividendsIncomeStatementImpact_019ff749-be43-7ca9-bb70-c7be1f2167da" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_PreferredStockDividendsIncomeStatementImpact"/>
    <link:calculationArc order="2" weight="-1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_us-gaap_UndistributedEarningsLossAvailableToCommonShareholdersBasic_019ff749-be43-7f95-a379-06da67ce3169" xlink:to="loc_us-gaap_PreferredStockDividendsIncomeStatementImpact_019ff749-be43-7ca9-bb70-c7be1f2167da" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_NetIncomeLossAvailableToCommonStockholdersDiluted_019ff749-be43-7106-bfc5-ec667398d10b" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_NetIncomeLossAvailableToCommonStockholdersDiluted"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_NetIncomeLossAvailableToCommonStockholdersBasic_019ff749-be43-7760-9009-56be63ba9e87" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_NetIncomeLossAvailableToCommonStockholdersBasic"/>
    <link:calculationArc order="1" weight="1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_us-gaap_NetIncomeLossAvailableToCommonStockholdersDiluted_019ff749-be43-7106-bfc5-ec667398d10b" xlink:to="loc_us-gaap_NetIncomeLossAvailableToCommonStockholdersBasic_019ff749-be43-7760-9009-56be63ba9e87" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_zvra_FairValueAdjustmentOfWarrantsNetOfTax_019ff749-be43-7a39-9a6a-fe38b9f279f5" xlink:href="zvra-20260930.xsd#zvra_FairValueAdjustmentOfWarrantsNetOfTax"/>
    <link:calculationArc order="2" weight="-1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_us-gaap_NetIncomeLossAvailableToCommonStockholdersDiluted_019ff749-be43-7106-bfc5-ec667398d10b" xlink:to="loc_zvra_FairValueAdjustmentOfWarrantsNetOfTax_019ff749-be43-7a39-9a6a-fe38b9f279f5" xlink:type="arc"/>
  </link:calculationLink>
  <link:roleRef roleURI="http://zevra.com/role/LeasesScheduleofComponentofLeaseExpensesDetails" xlink:type="simple" xlink:href="zvra-20260930.xsd#LeasesScheduleofComponentofLeaseExpensesDetails"/>
  <link:calculationLink xlink:role="http://zevra.com/role/LeasesScheduleofComponentofLeaseExpensesDetails" xlink:type="extended">
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_LeaseCost_019ff749-be43-74c6-822d-5866dfeb59bd" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_LeaseCost"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_SubleaseIncome_019ff749-be43-7264-944e-3660160d293e" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_SubleaseIncome"/>
    <link:calculationArc order="1" weight="-1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_us-gaap_LeaseCost_019ff749-be43-74c6-822d-5866dfeb59bd" xlink:to="loc_us-gaap_SubleaseIncome_019ff749-be43-7264-944e-3660160d293e" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_OperatingLeaseCost_019ff749-be43-77f7-8f9f-96eb48fccbe7" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_OperatingLeaseCost"/>
    <link:calculationArc order="2" weight="1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_us-gaap_LeaseCost_019ff749-be43-74c6-822d-5866dfeb59bd" xlink:to="loc_us-gaap_OperatingLeaseCost_019ff749-be43-77f7-8f9f-96eb48fccbe7" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ShortTermLeaseCost_019ff749-be43-75d3-b645-c40ce531aa1d" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_ShortTermLeaseCost"/>
    <link:calculationArc order="3" weight="1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_us-gaap_LeaseCost_019ff749-be43-74c6-822d-5866dfeb59bd" xlink:to="loc_us-gaap_ShortTermLeaseCost_019ff749-be43-75d3-b645-c40ce531aa1d" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_VariableLeaseCost_019ff749-be43-7def-8dc7-b11878752fb9" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_VariableLeaseCost"/>
    <link:calculationArc order="4" weight="1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_us-gaap_LeaseCost_019ff749-be43-74c6-822d-5866dfeb59bd" xlink:to="loc_us-gaap_VariableLeaseCost_019ff749-be43-7def-8dc7-b11878752fb9" xlink:type="arc"/>
  </link:calculationLink>
  <link:roleRef roleURI="http://zevra.com/role/LeasesScheduleOfSupplementalBalanceSheetInformationRelatedToLeasesDetails" xlink:type="simple" xlink:href="zvra-20260930.xsd#LeasesScheduleOfSupplementalBalanceSheetInformationRelatedToLeasesDetails"/>
  <link:calculationLink xlink:role="http://zevra.com/role/LeasesScheduleOfSupplementalBalanceSheetInformationRelatedToLeasesDetails" xlink:type="extended">
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_OperatingLeaseLiability_019ff749-be43-7032-9dc7-afcdf5cc2e0e" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_OperatingLeaseLiability"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_OperatingLeaseLiabilityNoncurrent_019ff749-be43-7964-b079-f179244bbdd5" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_OperatingLeaseLiabilityNoncurrent"/>
    <link:calculationArc order="1" weight="1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_us-gaap_OperatingLeaseLiability_019ff749-be43-7032-9dc7-afcdf5cc2e0e" xlink:to="loc_us-gaap_OperatingLeaseLiabilityNoncurrent_019ff749-be43-7964-b079-f179244bbdd5" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_OperatingLeaseLiabilityCurrent_019ff749-be43-78d6-9226-68ee91abf049" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_OperatingLeaseLiabilityCurrent"/>
    <link:calculationArc order="2" weight="1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_us-gaap_OperatingLeaseLiability_019ff749-be43-7032-9dc7-afcdf5cc2e0e" xlink:to="loc_us-gaap_OperatingLeaseLiabilityCurrent_019ff749-be43-78d6-9226-68ee91abf049" xlink:type="arc"/>
  </link:calculationLink>
  <link:roleRef roleURI="http://zevra.com/role/LeasesScheduleofMaturitiesofOperatingLeaseLiabilitiesDetails" xlink:type="simple" xlink:href="zvra-20260930.xsd#LeasesScheduleofMaturitiesofOperatingLeaseLiabilitiesDetails"/>
  <link:calculationLink xlink:role="http://zevra.com/role/LeasesScheduleofMaturitiesofOperatingLeaseLiabilitiesDetails" xlink:type="extended">
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_LesseeOperatingLeaseLiabilityPaymentsDue_019ff749-be43-72d2-b623-6a5fe9824e94" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_LesseeOperatingLeaseLiabilityPaymentsDue"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_LesseeOperatingLeaseLiabilityUndiscountedExcessAmount_019ff749-be43-7b0b-8466-0327f582e6fe" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_LesseeOperatingLeaseLiabilityUndiscountedExcessAmount"/>
    <link:calculationArc order="1" weight="1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_us-gaap_LesseeOperatingLeaseLiabilityPaymentsDue_019ff749-be43-72d2-b623-6a5fe9824e94" xlink:to="loc_us-gaap_LesseeOperatingLeaseLiabilityUndiscountedExcessAmount_019ff749-be43-7b0b-8466-0327f582e6fe" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_OperatingLeaseLiability_019ff749-be43-76f7-88ca-f11977776050" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_OperatingLeaseLiability"/>
    <link:calculationArc order="2" weight="1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_us-gaap_LesseeOperatingLeaseLiabilityPaymentsDue_019ff749-be43-72d2-b623-6a5fe9824e94" xlink:to="loc_us-gaap_OperatingLeaseLiability_019ff749-be43-76f7-88ca-f11977776050" xlink:type="arc"/>
  </link:calculationLink>
  <link:roleRef roleURI="http://zevra.com/role/LeasesScheduleofMaturitiesofOperatingLeaseLiabilitiesDetails_1" xlink:type="simple" xlink:href="zvra-20260930.xsd#LeasesScheduleofMaturitiesofOperatingLeaseLiabilitiesDetails_1"/>
  <link:calculationLink xlink:role="http://zevra.com/role/LeasesScheduleofMaturitiesofOperatingLeaseLiabilitiesDetails_1" xlink:type="extended">
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_LesseeOperatingLeaseLiabilityPaymentsDue_019ff749-be43-70b4-a864-1d0d272049b3" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_LesseeOperatingLeaseLiabilityPaymentsDue"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_LesseeOperatingLeaseLiabilityPaymentsRemainderOfFiscalYear_019ff749-be43-79e3-bd45-83ba485102e4" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_LesseeOperatingLeaseLiabilityPaymentsRemainderOfFiscalYear"/>
    <link:calculationArc order="1" weight="1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_us-gaap_LesseeOperatingLeaseLiabilityPaymentsDue_019ff749-be43-70b4-a864-1d0d272049b3" xlink:to="loc_us-gaap_LesseeOperatingLeaseLiabilityPaymentsRemainderOfFiscalYear_019ff749-be43-79e3-bd45-83ba485102e4" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_LesseeOperatingLeaseLiabilityPaymentsDueYearThree_019ff749-be43-7e14-b531-7ae6017da964" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_LesseeOperatingLeaseLiabilityPaymentsDueYearThree"/>
    <link:calculationArc order="2" weight="1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_us-gaap_LesseeOperatingLeaseLiabilityPaymentsDue_019ff749-be43-70b4-a864-1d0d272049b3" xlink:to="loc_us-gaap_LesseeOperatingLeaseLiabilityPaymentsDueYearThree_019ff749-be43-7e14-b531-7ae6017da964" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_LesseeOperatingLeaseLiabilityPaymentsDueNextTwelveMonths_019ff749-be43-778d-8933-9ce347c832c3" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_LesseeOperatingLeaseLiabilityPaymentsDueNextTwelveMonths"/>
    <link:calculationArc order="3" weight="1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_us-gaap_LesseeOperatingLeaseLiabilityPaymentsDue_019ff749-be43-70b4-a864-1d0d272049b3" xlink:to="loc_us-gaap_LesseeOperatingLeaseLiabilityPaymentsDueNextTwelveMonths_019ff749-be43-778d-8933-9ce347c832c3" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_LesseeOperatingLeaseLiabilityPaymentsDueYearTwo_019ff749-be43-729e-904d-3e28299cc812" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_LesseeOperatingLeaseLiabilityPaymentsDueYearTwo"/>
    <link:calculationArc order="4" weight="1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_us-gaap_LesseeOperatingLeaseLiabilityPaymentsDue_019ff749-be43-70b4-a864-1d0d272049b3" xlink:to="loc_us-gaap_LesseeOperatingLeaseLiabilityPaymentsDueYearTwo_019ff749-be43-729e-904d-3e28299cc812" xlink:type="arc"/>
  </link:calculationLink>
</link:linkbase>
