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                            March 3, 2023

       R. LaDuane Clifton
       Chief Financial Officer
       Zevra Therapeutics, Inc.
       1180 Celebration Boulevard, Suite 103
       Celebration, FL 34747

                                                        Re: Zevra Therapeutics,
Inc.
                                                            Preliminary Proxy
Statement on Schedule 14A
                                                            Filed February 27,
2023
                                                            File No. 001-36913

       Dear R. LaDuane Clifton:

              We have reviewed your filing and have the following comments. In
some of our
       comments, we may ask you to provide us with information so we may better
understand your
       disclosure.

               Please respond to these comments by providing the requested
information or advise us as
       soon as possible when you will respond. If you do not believe our
comments apply to your facts
       and circumstances, please tell us why in your response.

               After reviewing your response to these comments, we may have
additional comments.
       All defined terms have the same meaning as in the proxy statement.

       Preliminary Proxy Statement on Schedule 14A filed February 27, 2023

       When are stockholder proposals and director nominations due for next
year's annual meeting?,
       page 10

   1.                                                   Please provide the
disclosure required by Rule 14a-5(e)(4). See Item 1(c) of Schedule
                                                        14A and Rule 14d-19(b).
       Annex A. Information Concerning Participants in the Company's
Solicitation of Proxies, page A-
       1

   2.                                                   Please disclose the
information required by Item 5(b)(1)(iii) of Schedule 14A, which
                                                        requires you to
disclose whether or not any of the specified individuals have been
                                                        involved in any
proceedings.
 R. LaDuane Clifton
Zevra Therapeutics, Inc.
March 3, 2023
Page 2
General

3.       For proposals 2 and 3, please disclose the effect of an "ABSTAIN"
vote. See Item 21(b)
         of Schedule 14A.
        We remind you that the filing persons are responsible for the accuracy
and adequacy of
their disclosures, notwithstanding any review, comments, action or absence of
action by the staff.

       Please direct any questions to Michael Killoy at (202) 551-7576 or
Christina Chalk at
(202) 551-3263.



FirstName LastNameR. LaDuane Clifton                        Sincerely,
Comapany NameZevra Therapeutics, Inc.
                                                            Division of
Corporation Finance
March 3, 2023 Page 2                                        Office of Mergers &
Acquisitions
FirstName LastName